CAS · 16617-46-2
Product Overview
3-Amino-4-pyrazolecarbonitrile is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White to off white powder |
|---|---|
| Assay: | 98% min |
| Water: | 0.5% max |
Applications
1. Pharmaceutical Intermediates
3-Amino-4-pyrazolecarbonitrile is widely used as a key intermediate in the synthesis of various bioactive compounds and drug candidates, including:
Anticancer agents
Its pyrazole ring is found in many kinase inhibitors and antitumor compounds. The nitrile and amino groups provide functional handles for further derivatization, such as forming amides, imines, or heteroaromatic extensions.
Anti-inflammatory and analgesic drugs
Pyrazole-based scaffolds are commonly used in the development of COX-2 inhibitors and other pain-relieving agents.
Antiviral and antimicrobial agents
Modifications at the amino or nitrile positions can yield compounds with broad biological activity, including potential activity against bacteria, fungi, or viruses.
2. Agrochemical Synthesis
Acts as a building block for herbicides, fungicides, and insecticides.
The pyrazole core contributes to the selectivity and potency of active ingredients used in crop protection.
Facilitates synthesis of analogs with targeted activity due to its reactivity and compatibility with various substitution reactions.
3. Heterocyclic and Fine Chemical Synthesis
Serves as a precursor for the synthesis of more complex pyrazole derivatives, pyrazolopyrimidines, and pyrazolotriazines, which are important in medicinal and materials chemistry.
Useful in multi-step organic synthesis due to its bifunctional nature (amino and nitrile groups), allowing diverse reactions such as:
Cyclization
Amidation
Condensation
Nucleophilic substitution
4. Research and Development
Commonly used in academic and industrial research for structure-activity relationship (SAR) studies involving pyrazole frameworks.
Helps in the exploration of novel drug-like molecules due to its favorable structural features.
Benefits
1. Dual Functional Groups for Versatile Chemistry
The –NH₂ and –CN groups allow for a wide range of chemical transformations.
Supports selective derivatization for producing various substituted heterocycles, making it a versatile synthetic handle.
2. High Reactivity and Compatibility
Reacts well under mild conditions with electrophiles and nucleophiles.
Compatible with microwave-assisted, green, or solid-phase synthesis techniques, which are preferred in modern drug discovery.
3. Pharmacophore-Rich Scaffold
The pyrazole ring is a privileged structure in medicinal chemistry due to its favorable:
Hydrogen bonding capacity
Electron density
Binding to biological targets
This makes 3-amino-4-pyrazolecarbonitrile an ideal starting point for developing molecules with high biological activity.
4. Commercial Availability and Cost-Effectiveness
Readily available from chemical suppliers in bulk quantities, making it suitable for both laboratory R&D and pilot-scale production.
Cost-effective intermediate for synthesizing high-value end products.
5. Facilitates Novel Molecule Development
Supports library generation in combinatorial chemistry due to its modular structure.
Encourages the exploration of novel lead compounds in drug discovery programs.
Conclusion
3-Amino-4-pyrazolecarbonitrile (CAS 16617-46-2) is a highly valuable intermediate in pharmaceutical and agrochemical synthesis. Its pyrazole ring, combined with amino and nitrile functionalities, offers rich chemistry for the construction of diverse, biologically relevant compounds. Whether used in drug development, crop protection, or heterocyclic synthesis, its reactivity, versatility, and favorable structural features make it a cornerstone building block in modern organic and medicinal chemistry.
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