CAS · 443-88-9
Product Overview
2,6-Dimethylfluorobenzene is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Colourless or light yellow liquid |
|---|---|
| Purity: | 99% min |
| Density: | 0.988 g/mL |
| Boiling Point: | 147–148 °C |
| Moisture: | 0.5% max |
Applications
2,6-Dimethylfluorobenzene (CAS 443-88-9) is an aromatic fluorinated compound widely used as an intermediate in pharmaceutical, agrochemical, and fine chemical synthesis. The presence of both fluorine and methyl substituents on the benzene ring provides a unique balance of electronic and steric properties, making it a valuable precursor for the preparation of active pharmaceutical ingredients, fluorinated materials, and specialty organic compounds. It is often employed in cross-coupling reactions such as Suzuki or Buchwald–Hartwig reactions to introduce functional groups into aromatic frameworks. Additionally, it serves as a building block in the synthesis of catalysts, liquid crystals, and high-performance polymers where thermal and chemical stability are required.
Benefits
The benefits of 2,6-dimethylfluorobenzene arise from its chemical stability, selective reactivity, and ability to fine-tune molecular properties through fluorine substitution. The fluorine atom enhances the compound's lipophilicity, metabolic stability, and electronic effects, which are particularly advantageous in the design of pharmaceuticals and agrochemicals. The two methyl groups provide steric hindrance that directs regioselective transformations, enabling precise control in synthetic routes. Furthermore, the compound's compatibility with various catalytic systems allows efficient incorporation into complex molecular architectures, reducing synthesis time and improving overall yields.
Conclusion
2,6-Dimethylfluorobenzene is a valuable fluorinated intermediate with important applications in pharmaceuticals, agrochemicals, and advanced materials. Its combination of fluorine and methyl substituents offers a unique balance of stability and reactivity, making it highly effective in the synthesis of functionalized aromatic compounds. By supporting precise molecular design and high-performance material development, it remains an essential tool in modern chemical synthesis and industrial innovation.
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