CAS · 2364-75-2
Product Overview
2-Ethyl-3-hydroxy-6-methylpyridine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white to white crystalline powder |
|---|---|
| Assay | 99% min |
| Solubility | Soluble in ethanol, practically insoluble in water |
| Melting point | 167℃ to 170℃ |
| Identification IR | Conforms |
| Identification HPLC | Conforms |
| Total impurity | 1% max |
| Max single impurity | 0.1% max |
| Water | 1% max |
| Ethanol | 0.5% max |
| Residue on ignition | 0.1% max |
| Heavy metal | 10 ppm max |
Applications
2-Ethyl-3-hydroxy-6-methylpyridine is an important intermediate in pharmaceutical and fine chemical synthesis. It is widely used in the production of vitamin B3 (niacin) derivatives and other bioactive pyridine-based compounds. The hydroxy-pyridine scaffold allows its incorporation into drugs targeting metabolic, cardiovascular, and neurological pathways. Additionally, it is used in research and development for the synthesis of heterocyclic molecules, agrochemicals, and functionalized pyridine derivatives. Its chemical versatility makes it valuable in medicinal chemistry for structure–activity relationship (SAR) studies and in materials science for designing nitrogen-containing ligands and chelating agents.
Benefits
The benefits of 2-Ethyl-3-hydroxy-6-methylpyridine arise from its stable pyridine framework combined with reactive hydroxy and alkyl substituents. The hydroxy group enables selective functionalization, oxidation, and derivatization reactions, while the methyl and ethyl groups modulate steric and electronic properties, enhancing synthetic flexibility. Its relatively high chemical stability and compatibility with various reaction conditions make it easy to handle and incorporate into multi-step synthesis. The compound serves as a reliable building block for developing bioactive molecules, optimizing pharmacological properties, and creating functional nitrogen-containing heterocycles.
Conclusion
2-Ethyl-3-hydroxy-6-methylpyridine is a versatile intermediate in pharmaceutical, agrochemical, and materials research. Its combination of reactive hydroxy functionality and substituted pyridine scaffold provides synthetic flexibility, stability, and structural utility. By supporting the construction of bioactive molecules and functional heterocycles, it remains an essential building block in medicinal chemistry and fine chemical synthesis.
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