2-Iodo-4-methoxypyrimidine

2-Iodo-4-methoxypyrimidine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

2-Iodo-4-methoxypyrimidine is primarily used in medicinal chemistry and drug discovery as a building block for synthesizing nucleoside analogues, kinase inhibitors, and other heterocyclic bioactive compounds. Its iodine substituent is highly reactive in palladium-catalyzed cross-coupling reactions such as Suzuki, Sonogashira, and Buchwald–Hartwig couplings, enabling the construction of diverse molecular frameworks. In organic synthesis, it serves as an intermediate for functionalizing the pyrimidine ring and creating heteroaryl derivatives. The compound is also applied in chemical research to explore structure-activity relationships, develop new synthetic methodologies, and construct ligands for coordination chemistry.

The benefits of 2-Iodo-4-methoxypyrimidine include its reactive iodine substituent, versatile functionalization potential, and stability. The iodine atom allows for highly efficient cross-coupling and substitution reactions, facilitating rapid and selective synthesis of complex molecules. The methoxy group contributes electron density to the pyrimidine ring, enhancing reactivity and modulating biological properties in downstream compounds. Its solid, stable form allows easy handling and storage, while its compatibility with common organic solvents and catalysts makes it suitable for multi-step synthetic sequences. Overall, it provides both structural flexibility and chemical reliability for drug discovery and advanced synthesis.

In summary, 2-Iodo-4-methoxypyrimidine is a halogenated pyrimidine intermediate widely used in medicinal chemistry, organic synthesis, and chemical research. Its combination of a reactive iodine atom and methoxy-functionalized pyrimidine scaffold enables selective derivatization and cross-coupling reactions. With its chemical versatility, stability, and applicability in constructing biologically active molecules, it serves as a valuable building block for pharmaceuticals, heterocyclic compounds, and functionalized organic materials.

Previous

Cis-methyl 2-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate丨CAS 170299-60-2

Next

5-Bromo-1-Methyl-1,2,4-Triazole丨CAS 16681-72-4