CAS · 52328-05-9
Product Overview
O-Methylisourea hemisulfate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White crystal or crystalline powder |
|---|---|
| Assay | 98.5% min |
| Melting point | 150.0–157.0 °C |
| Identification | Identification of sulfate reaction |
| pH | 4.5–7.0 |
| Loss on drying | 1.0% max |
Applications
O-Methylisourea hemisulfate is a highly reactive organic compound widely used as a reagent and intermediate in chemical synthesis, pharmaceutical development, and biochemical research. It is primarily applied in the preparation of guanidine derivatives, amidines, and heterocyclic compounds, which are key building blocks in pharmaceuticals, agrochemicals, and fine chemicals. Its reactivity makes it suitable for the methylation of amino groups and the synthesis of substituted guanidines, which are frequently used in antiviral, anticancer, and enzyme inhibitor research. In biochemical studies, O-Methylisourea hemisulfate is utilized to modify proteins, peptides, and nucleic acids through selective guanidination reactions, enabling investigations of protein structure, function, and interactions. It is also employed in the preparation of analytical standards and intermediates for high-value chemical transformations.
Benefits
The benefits of O-Methylisourea hemisulfate arise from its high chemical reactivity, solubility in aqueous and polar organic solvents, and selectivity in guanidination reactions. Its hemisulfate form enhances stability and handling compared with the free base, reducing the risk of decomposition while maintaining reactivity under controlled conditions. The compound allows efficient introduction of methylguanidine functionality into amines, peptides, or other nucleophilic substrates, supporting precise chemical modifications with high yield. Its compatibility with standard laboratory procedures, mild reaction conditions, and reproducibility in synthesis make it a reliable reagent for both small-scale research and industrial applications. These characteristics enable streamlined production of pharmaceuticals, fine chemicals, and biochemical probes.
Conclusion
O-Methylisourea hemisulfate is a versatile and reactive intermediate used in pharmaceutical, chemical, and biochemical research. Its ability to selectively introduce guanidine functionality, combined with stability and solubility advantages, makes it an essential reagent for the synthesis of guanidine derivatives, heterocycles, and protein modifications. By facilitating efficient chemical transformations, precise functionalization, and reliable experimental outcomes, O-Methylisourea hemisulfate remains an important building block in modern synthetic chemistry and biochemical studies.
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