CAS · 863329-66-2
Product Overview
2-deoxy-2-fluoro-2-C-methyluridine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off-white powder |
|---|---|
| Identification | The retention time corresponds to the reference standard |
| Purity (HPLC) | 99% min |
| Melting point | 218.0~228.0 °C |
| Specific rotation | +85.0~+93 ° |
| Loss on drying | 1.0% max |
| Residue on ignition | 0.5% max |
| Single impurity | 0.5% max |
| Total impurities | 1.0% max |
Applications
2-Deoxy-2-fluoro-2-C-methyluridine is primarily used as a nucleoside analogue in pharmaceutical and biomedical research. It serves as a key intermediate in the synthesis of antiviral agents, particularly those targeting RNA viruses. The compound is applied in the development of nucleoside-based therapeutics for inhibiting viral replication by interfering with viral polymerase activity. Additionally, it is used in structure–activity relationship studies to explore modifications on the sugar moiety of nucleosides, enabling the design of potent and selective antiviral drugs. The compound is also employed in chemical and enzymatic studies as a substrate for evaluating nucleoside metabolism and enzymatic incorporation into nucleic acids.
Benefits
This compound offers several advantages due to its structural modifications. The 2-fluoro substitution enhances metabolic stability and resistance to enzymatic degradation, improving the pharmacokinetic properties of derived therapeutics. The 2-C-methyl modification provides steric hindrance that can increase selectivity toward viral enzymes and reduce off-target effects. Its nucleoside structure allows facile incorporation into synthetic pathways for nucleoside analogues, supporting efficient drug discovery workflows. Additionally, the compound is chemically stable under standard storage and reaction conditions, ensuring reproducible results in research and synthetic applications.
Conclusion
2-Deoxy-2-fluoro-2-C-methyluridine is a valuable nucleoside analogue intermediate with broad applications in antiviral drug development and biochemical research. Its utility in synthesizing metabolically stable and selective nucleoside therapeutics, combined with benefits such as enzymatic resistance, chemical stability, and synthetic versatility, makes it an essential building block in modern medicinal chemistry. The compound continues to support the discovery and development of novel antiviral agents and nucleoside-based therapeutics.
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