CAS · 934816-82-7
Product Overview
2-Chlorotrityl chloride is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Yellow or brown beads |
|---|---|
| Loss on drying | Reported |
| Bead Size | 100 - 200 mesh |
| Cross-Linking | 1% DVB |
| Loading | 0.4 - 3.0 mmol/g |
| Swelling in DCM (ml/g) | 1.0 - 8.0 ml/g |
| Swelling in DMF (ml/g) | 1.0 - 8.0 ml/g |
| IR Spectrum | In accordance with the structure |
Applications
2-Chlorotrityl chloride is a widely used solid-phase support and linker in peptide synthesis and organic synthesis. It is primarily employed as a resin-bound functional group for the attachment of amino acids, allowing the stepwise construction of peptides via solid-phase peptide synthesis (SPPS). Its acid-labile nature permits mild cleavage of the synthesized peptide without damaging sensitive side-chain protecting groups. Beyond peptide synthesis, it is also used as a protecting group or linker in the preparation of small molecules, combinatorial libraries, and other functionalized organic compounds where controlled release or selective attachment is needed. Its stability under basic conditions and selective reactivity with nucleophiles make it highly versatile in complex synthetic workflows.
Benefits
The benefits of 2-Chlorotrityl chloride include its strong reactivity toward nucleophiles, mild acid-labile cleavage, and compatibility with a wide range of reaction conditions. Its use allows the efficient synthesis of peptides with high purity, minimal racemization, and retention of side-chain protection. The trityl framework provides steric hindrance, reducing undesired side reactions and improving selectivity in peptide chain elongation. Its stability in organic solvents and under basic conditions makes it reliable for multi-step syntheses, while its mild cleavage conditions help preserve the integrity of sensitive functional groups.
Conclusion
2-Chlorotrityl chloride is a key resin and linker in solid-phase peptide synthesis and organic synthesis. Its selective reactivity, mild acid-labile cleavage, and compatibility with diverse synthetic conditions make it an essential tool for constructing peptides and functionalized molecules with high efficiency and purity. By enabling controlled attachment and release, it supports precise molecular assembly in research and industrial applications.
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