CAS · 9050-31-1
Product Overview
Hypromellose Phthalate (HPMCP) | CAS 9050-31-1 is a highly versatile cellulose derivative widely used in the pharmaceutical and nutraceutical industries. Known for its effectiveness as an enteric coating agent, it plays a crucial role in ensuring the controlled release and stability of oral dosage forms.
Product Specifications
| Property | Specification |
|---|---|
| Grade | USP42 |
| Appearance | White or almost white granular solid, no smell, no taste |
| Identification | The infrared spectroscopic test result of the test article and that of the reference substance are basically the same |
| Viscosity | Standard: 55 mPa.s, Range: 80%~120% |
| Chloride | 0.07% max |
| Free acid | 1.0% max |
| Moisture | 5.0% max |
| Residue on ignition | 0.2% max |
| Heavy metals | 0.001% max |
| Phthaloyl content | 21.0% - 27.0% |
Applications
1.Pharmaceutical Industry:
- Enteric Coatings: HPMCP is primarily used to coat tablets, capsules, and granules, ensuring that the active ingredients are protected from the acidic environment of the stomach. This allows the medication to reach the intestines intact, where it can be released at the optimal absorption site.
- Controlled Release Formulations: By enabling the precise control of where and when the drug is released, Hypromellose Phthalate enhances the efficacy of medications, particularly for drugs sensitive to gastric acid or designed for targeted delivery.
- Sustained Release Applications: In some formulations, HPMCP contributes to sustained drug release, providing consistent therapeutic effects over extended periods.
2. Dietary Supplements:
- In nutraceutical applications, Hypromellose Phthalate ensures the stability and targeted release of supplements, such as probiotics or enzymes, that may be degraded by stomach acid.
Benefits
1.Enhanced Stability:
- Acid Resistance: HPMCP provides robust protection for acid-sensitive active pharmaceutical ingredients (APIs), ensuring their stability until they reach the intended site of action in the intestines.
- Moisture Barrier: It acts as a moisture barrier, protecting the formulation from environmental humidity and extending shelf life.
2.Improved Bioavailability:
- By preventing premature disintegration in the stomach, Hypromellose Phthalate allows for precise delivery to the intestinal tract, enhancing the bioavailability and therapeutic efficacy of the active ingredients.
3.Patient-Centric Design:
- Reduced Side Effects: Enteric coatings made with HPMCP reduce gastric irritation, making it ideal for patients with sensitive stomachs or those taking medications prone to causing gastric discomfort.
- Enhanced Tolerance: For medications requiring delayed absorption, HPMCP ensures a gentler pharmacokinetic profile.
4.Formulation Flexibility:
- Wide pH Range: Hypromellose Phthalate dissolves in the mildly acidic to neutral pH of the intestines, making it suitable for a variety of controlled-release formulations.
- Versatile Applications: Compatible with multiple formulation techniques, including spray coating and fluid bed coating processes.
Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.