CAS · 144100-07-2
Product Overview
2-Bromo-6-fluoropyridine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Light yellow liquid |
|---|---|
| Purity (GC): | 99% min |
| Moisture: | 0.5% max |
| Single impurity: | 0.5% max |
Applications
2-Bromo-6-fluoropyridine is a halogenated heteroaryl compound widely used as an intermediate in pharmaceutical, agrochemical, and materials chemistry. It is primarily employed in cross-coupling reactions such as Suzuki, Stille, and Buchwald-Hartwig reactions to construct biaryl and heteroaryl scaffolds, which are key structures in drug discovery and development. The compound is also utilized in the synthesis of fluorinated pyridine derivatives, which serve as building blocks for active pharmaceutical ingredients (APIs), enzyme inhibitors, and receptor modulators. Additionally, it finds application in the preparation of agrochemicals, specialty chemicals, and heterocyclic compounds for materials science research, where the bromine and fluorine substituents provide tunable electronic and steric properties.
Benefits
2-Bromo-6-fluoropyridine offers significant advantages due to its halogen substitution pattern and reactive pyridine ring. The bromine atom allows selective and efficient cross-coupling reactions, while the fluorine atom enhances metabolic stability, lipophilicity, and electronic characteristics of the resulting molecules, which is particularly beneficial in pharmaceutical design. Its crystalline and stable form ensures ease of handling, storage, and incorporation into multi-step syntheses. The compound's high reactivity and versatility make it suitable for constructing complex heterocyclic structures with high selectivity and yield, supporting both research-scale and industrial-scale applications.
Conclusion
2-Bromo-6-fluoropyridine is a valuable intermediate in the synthesis of fluorinated heteroaryl compounds for pharmaceuticals, agrochemicals, and materials science. Its combination of halogen reactivity, pyridine functionality, and stability makes it an indispensable building block for constructing bioactive molecules and functional materials. The compound continues to play a crucial role in drug discovery, fine chemical synthesis, and advanced heterocyclic chemistry.
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