CAS · 295-37-4
Product Overview
1,4,8,11-Tetraazacyclotetradecane is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White flocculent solid |
|---|---|
| Identification | Conforms |
| Water content | 1% max |
| Toluene | 1% max |
| Purity | 98.5% min |
Applications
1,4,8,11-Tetraazacyclotetradecane (CAS 295-37-4), commonly known as cyclam, is a macrocyclic tetraamine widely used in coordination chemistry, medicinal chemistry, and materials science. Its four nitrogen donor atoms allow for strong chelation with transition metals, making it an ideal ligand for the preparation of stable metal complexes with copper, nickel, cobalt, and other metals. These complexes are employed in catalysis, electrochemical applications, and as contrast agents in magnetic resonance imaging (MRI). In medicinal chemistry, cyclam derivatives are explored for antiviral, antibacterial, and anticancer agents, particularly in designing metal-based therapeutics. The macrocyclic structure also enables its use in supramolecular chemistry, molecular recognition, and the construction of host–guest systems for selective ion sensing and separation processes.
Benefits
The benefits of 1,4,8,11-tetraazacyclotetradecane stem from its strong metal-binding ability, chemical stability, and structural rigidity. The macrocyclic framework provides high thermodynamic and kinetic stability to metal complexes, reducing decomposition or ligand exchange under harsh conditions. Its multiple nitrogen atoms allow fine-tuning of electronic properties and coordination geometry, which is advantageous in catalysis and sensor design. Additionally, cyclam is soluble in polar solvents and compatible with various chemical modifications, facilitating functionalization for targeted applications. Its ability to form selective and stable complexes makes it valuable for both research and industrial purposes, from drug development to advanced materials.
Conclusion
1,4,8,11-Tetraazacyclotetradecane is a versatile macrocyclic ligand with broad applications in coordination chemistry, catalysis, medicinal chemistry, and materials science. Its strong chelating properties, structural stability, and modifiability enable the design of stable metal complexes, bioactive compounds, and supramolecular systems. By providing reliable and tunable chemical interactions, this compound continues to be a critical tool for advancing research and practical applications in multiple scientific fields.
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