CAS · 7688-25-7
Product Overview
1,4-Bis(diphenylphosphino)butane is a high-purity catalysts-auxiliary-agent supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off-white solid |
|---|---|
| Assay (HPLC) | 98% min |
| NMR | H-NMR / P-NMR |
| Melting point (MP) | 132–136 °C |
| Solvent | 0.5% max |
Applications
1,4-Bis(diphenylphosphino)butane is widely used as a bidentate phosphine ligand in coordination chemistry and homogeneous catalysis. It is commonly applied in transition-metal-catalyzed reactions such as hydrogenation, hydroformylation, cross-coupling, and carbon–heteroatom bond-forming processes. The ligand coordinates strongly with metals including palladium, rhodium, ruthenium, and nickel, forming stable chelate complexes that are useful in pharmaceutical, fine chemical, and materials synthesis. In research and process development, it is employed to tune catalyst activity, selectivity, and stability, enabling optimization of reaction efficiency and product distribution. The compound is also used in organometallic studies to investigate ligand effects on metal center geometry, electronic properties, and catalytic mechanisms.
Benefits
The compound offers several advantages arising from its bidentate structure and flexible butane backbone. The two diphenylphosphino groups provide strong electron donation and stable chelation, enhancing catalyst robustness and longevity during reactions. Its bite angle and conformational flexibility allow effective modulation of metal reactivity, which can lead to improved catalytic performance and selectivity. The ligand exhibits good solubility in common organic solvents, facilitating homogeneous reaction conditions and uniform catalyst dispersion. Its well-defined structure and consistent coordination behavior support reproducible results across different catalytic systems. These benefits make it a reliable ligand for both exploratory research and scalable catalytic processes.
Conclusion
1,4-Bis(diphenylphosphino)butane is an important bidentate phosphine ligand used extensively in homogeneous catalysis and coordination chemistry. Its applications in transition-metal-catalyzed reactions, combined with benefits such as strong metal binding, tunable reactivity, and consistent performance, make it a valuable component in modern synthetic chemistry. The compound continues to support efficient catalyst design and the development of advanced chemical transformations.
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