CAS · 1460-02-2
Product Overview
1,3,5-Tri-tert-butylbenzene is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off-white crystalline powder |
|---|---|
| Purity (GC) | 98.0% min |
| Melting point | 70.0 ~ 75.0 °C |
Applications
1,3,5-Tri-tert-butylbenzene is primarily used as a specialized intermediate in organic synthesis and materials science. Its highly substituted aromatic structure makes it useful in the preparation of bulky ligands, sterically hindered catalysts, and organometallic complexes. It is also employed in the synthesis of high-performance polymers, antioxidants, and stabilizers, where the steric protection provided by the tert-butyl groups enhances thermal and oxidative stability. Additionally, it serves as a model compound in mechanistic studies of aromatic substitution reactions and in the development of novel aromatic compounds for pharmaceuticals and functional materials.
Benefits
The main benefits of 1,3,5-Tri-tert-butylbenzene include its chemical stability, steric bulk, and resistance to oxidation. The tert-butyl groups protect the aromatic ring from undesired reactions, enabling selective functionalization at less hindered positions. Its thermal stability and low reactivity under standard conditions make it suitable for high-temperature or rigorous synthetic processes. Moreover, the bulky substituents improve solubility in organic solvents and facilitate the design of sterically demanding ligands and intermediates. These characteristics provide chemists with a versatile and reliable building block for complex molecular design.
Conclusion
1,3,5-Tri-tert-butylbenzene is a valuable intermediate in organic synthesis, catalysis, and materials science. Its steric protection, chemical stability, and versatility enable selective reactions, high-performance polymer synthesis, and the design of specialized ligands and functional molecules. These properties make it a useful and practical compound for research and industrial applications requiring robust and well-defined aromatic frameworks.
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