CAS · 1433-27-8
Product Overview
1-Tert-Butyl-3 ethylcarbodimide is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Colorless to light yellow transparent liquid |
|---|---|
| Purity (GC): | 98% min |
| Identification by 1H-NMR: | Conforms to Structure |
| QNMR: | 96% min |
| Tert-Butylamine: | 0.5% max |
| Ethyl isothiocyanate: | 0.5% max |
Applications
1-Tert-Butyl-3-ethylcarbodiimide is widely used in peptide and protein synthesis as a coupling reagent to form amide bonds between carboxyl and amino groups. It is also employed in esterification reactions, facilitating the synthesis of esters under mild conditions. In medicinal and pharmaceutical chemistry, it serves as a key intermediate for producing bioactive molecules, small-molecule drugs, and peptide-based therapeutics. Beyond pharmaceuticals, it is applied in polymer chemistry and materials science for functionalizing polymers, creating crosslinked networks, and developing bioconjugates with dyes, antibodies, or other biomolecules. Its high efficiency in promoting coupling reactions also makes it valuable in laboratory-scale synthetic research for constructing complex molecular frameworks.
Benefits
The benefits of 1-Tert-Butyl-3-ethylcarbodiimide include its high reactivity, selectivity, and versatility. It efficiently activates carboxylic acids, allowing for rapid formation of amides and esters without significant side reactions or racemization of chiral centers. The tert-butyl and ethyl substituents provide steric protection, improving reagent stability and handling. It is compatible with a wide range of solvents and functional groups, enabling flexible application in multistep synthesis. Furthermore, it can be used in aqueous and organic systems, making it suitable for bioconjugation and peptide coupling in both laboratory and industrial settings. Its efficiency reduces reaction time and improves overall yield, enhancing productivity in synthetic workflows.
Conclusion
In summary, 1-Tert-Butyl-3-ethylcarbodiimide is a versatile carbodiimide reagent widely used in peptide synthesis, esterification, pharmaceutical development, and polymer functionalization. Its high reactivity, selectivity, and stability make it an essential tool for forming amide and ester bonds efficiently. With broad applicability and compatibility with diverse chemical systems, it serves as a key intermediate for constructing complex molecules, bioconjugates, and advanced synthetic products.
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