Dansyl chloride

Dansyl chloride is a high-purity analytical-reagents supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Fluorescent Labeling Agent

Dansyl chloride is a widely used fluorescent reagent for labeling:

Amines, amino acids, and peptides

Proteins and nucleotides

Enables detection in fluorescence-based analytical techniques:

HPLC (High-Performance Liquid Chromatography)

Capillary electrophoresis

Fluorescence spectroscopy

2. Biochemical and Biomedical Research

Useful in studying protein structure, enzyme kinetics, and receptor-ligand interactions

Helps visualize and quantify biomolecules in complex mixtures

Applied in fluorescent tagging of antibodies or substrates for bioimaging and diagnostics

3. Pharmaceutical and Metabolite Analysis

Facilitates derivatization of primary and secondary amines in drug compounds for:

Qualitative and quantitative analysis

Improved detection limits

Often used in metabolomics and bioavailability studies

4. Environmental and Food Testing

Detects trace amines and amino acids in environmental samples or food matrices by increasing sensitivity through fluorescence tagging

5. Synthetic Organic Chemistry

Serves as a sulfonylating reagent in functionalizing organic compounds

Helps introduce fluorescent tags into organic molecules, aiding in mechanistic studies and reaction monitoring

🌟 High Fluorescence Efficiency

Produces strong fluorescence under UV light (~340 nm excitation, ~520 nm emission), allowing sensitive detection even at very low concentrations.

🔬 Enhanced Detection in Analytical Techniques

Converts non-fluorescent molecules into fluorescent derivatives, making trace components easily identifiable in analytical workflows.

⚗️ Versatility in Labeling

Can tag a wide variety of biological and chemical molecules, including:

Amino acids (e.g., lysine, histidine)

Drugs and small-molecule analytes

Environmental pollutants

🧪 Improved Method Sensitivity

Dansylation improves chromatographic retention, UV absorbance, and fluorescence signal strength, enhancing both detection and separation efficiency.

🧫 Widely Validated

Well-established in literature and analytical protocols, offering reproducibility and standardization in a broad range of applications.

Dansyl chloride (CAS 605-65-2) is a powerful and highly versatile chemical widely employed in fluorescent labeling of biomolecules for analytical and research applications. Its ability to enhance the detection of trace compounds through strong fluorescence has made it indispensable in biochemistry, pharmaceutical research, metabolomics, and environmental analysis. With its strong signal output and reliable reactivity toward amines, dansyl chloride continues to be a critical reagent for modern scientific workflows, particularly in analytical chemistry and molecular diagnostics.

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