(S)-5-(Amidinoamino)-2-(benzoylamino)-N-(4-nitrophenyl)valeramide monohydrochloride
CAS 21653-40-7
CAS · 21653-40-7
Product Overview
(S)-5-(Amidinoamino)-2-(benzoylamino)-N-(4-nitrophenyl)valeramide monohydrochloride is a high-purity amino-acids supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Light yellow powder |
|---|---|
| Purity (HPLC) | 98% min |
| Clarity of solution | 0.3 gram in 2ml DMF clear solution |
| Water Content (K.F.) | 1% max |
| Loss on drying | 1% max (105°C, 2h) |
| IR | In accordance with the structure |
| Mass | In accordance with the structure |
| NMR | In accordance with the structure |
Applications
(S)-5-(Amidinoamino)-2-(benzoylamino)-N-(4-nitrophenyl)valeramide monohydrochloride is a specialized bioactive compound primarily used in pharmaceutical research and drug development. It functions as a protease inhibitor, targeting specific serine proteases involved in coagulation, inflammation, or microbial processes. The compound is utilized in the design and testing of novel therapeutic agents, including anticoagulants, antiviral, or antimicrobial drugs, where selective enzyme inhibition is critical. Its defined stereochemistry and functional groups allow for precise molecular interactions with enzyme active sites, making it valuable in structure-activity relationship (SAR) studies. Additionally, it serves as a reference standard or intermediate in synthetic pathways for developing analogs with optimized pharmacokinetics, bioavailability, and potency. Its solubility and stability in aqueous and organic media make it suitable for in vitro enzymatic assays, preclinical studies, and medicinal chemistry research.
Benefits
The benefits of this compound derive from its high specificity, stereochemical integrity, and functional versatility. Its (S)-configuration ensures selective binding to enzyme targets, enhancing potency and reducing off-target effects. The amidino and benzoylamino groups provide strong hydrogen bonding and electrostatic interactions with protease active sites, increasing inhibitory efficiency. The nitrophenyl moiety allows for further derivatization or conjugation in medicinal chemistry applications, facilitating SAR optimization and drug design. Its chemical stability under standard laboratory conditions ensures reproducible results in enzymatic assays and preclinical testing. Together, these properties make it a highly reliable tool for developing selective enzyme inhibitors, studying protease mechanisms, and generating new therapeutic candidates.
Conclusion
In summary, (S)-5-(Amidinoamino)-2-(benzoylamino)-N-(4-nitrophenyl)valeramide monohydrochloride is a valuable pharmaceutical intermediate and research compound with applications in protease inhibition, drug discovery, and enzymology. Its benefits-including high specificity, stereochemical integrity, and functional versatility-enable effective enzyme targeting, structure-activity studies, and analog development. By supporting precise medicinal chemistry research and preclinical studies, it continues to play a critical role in the development of novel therapeutic agents.
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