2′-Deoxyguanosine monohydrate

2′-Deoxyguanosine monohydrate is a high-purity nucleosides-nucleotides supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Molecular Biology and Biochemistry

2'-Deoxyguanosine monohydrate丨CAS 312693-72-4 is widely used as a substrate, standard, or control in various molecular and biochemical applications:

● DNA synthesis and sequencing: Serves as a precursor or substrate for in vitro DNA synthesis.

● Enzyme substrate: Used to study enzymes like deoxyguanosine kinase, nucleoside phosphorylases, and DNA polymerases.

● DNA damage and repair studies: A common target and marker in oxidative stress and mutagenesis research, where modifications to deoxyguanosine (e.g., formation of 8-oxo-dG) indicate oxidative DNA damage.

● Radiolabeling: Its base or sugar can be isotopically labeled for tracking DNA incorporation, replication, or degradation.

2. Pharmaceutical and Biomedical Research

● Antiviral and anticancer drug development: Serves as a scaffold or model for nucleoside analogues such as acyclovir, ganciclovir, and azidothymidine (AZT).

● Prodrug design: Utilized in research for drugs that mimic or incorporate into viral DNA to terminate replication.

● Toxicity and pharmacokinetics: Used in in vitro and in vivo studies to assess drug-nucleoside interactions and nucleoside transporter activity.

3. DNA Biosensors and Nanotechnology

● Biosensor calibration: Used in electrochemical and optical DNA biosensors that detect guanine oxidation.

● DNA-based nanostructures: Employed in designing and synthesizing nucleic acid nanomaterials for biotechnology applications.

4. Analytical Standards

● Used as a reference compound in HPLC, LC-MS, and capillary electrophoresis for analyzing nucleosides in biological samples such as blood, urine, or tissue.

✅ Biological Relevance

● As a core DNA component, 2'-deoxyguanosine is essential for studying cell replication, gene expression, and mutagenesis.

✅ High Purity for Research

● Commercially available in high purity, ensuring reproducibility and reliability in sensitive biochemical assays.

✅ Versatile Applications

● Compatible with radioisotope labeling, fluorescent tagging, and chemical modification, making it adaptable for various experimental designs.

✅ Oxidative Damage Biomarker

● Deoxyguanosine is the primary site for oxidation in DNA, producing 8-oxo-dG, a well-known biomarker for oxidative stress and carcinogenic processes.

2'-Deoxyguanosine monohydrate丨CAS 312693-72-4 is a cornerstone nucleoside for DNA-related research, spanning genetic, enzymatic, pharmaceutical, and diagnostic applications. Its role as a building block of DNA, its susceptibility to oxidative damage, and its versatility in chemical modification make it a critical reagent in both fundamental and applied biosciences. Researchers rely on it for assays involving DNA structure, function, repair, and for development of nucleoside-based therapeutics.

Previous

2,3-Dideoxyguanosine丨CAS 85326-06-3

Next

Ribosylthymine丨CAS 1463-10-1