CAS · 7413-34-5
Product Overview
Sodium methotrexate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Yellow crystalline powder |
|---|---|
| Assay | 98.0% to 102.0% |
| Identification | IR, UV Conform |
| Sodium | Positive |
| Water | 18.0% max |
| PH | 7.0 to 9.0 |
| Chromatographic purity - Single impurity | 0.5% max |
| Chromatographic purity - Total impurities | 2.0% max |
| Specific rotation | +19° to +24° |
| Bacterial endotoxin | 0.4 EU/mg max |
| Absorbance | 0.06% max |
| Residual solvents - Methanol | 3000 ppm max |
| Residual solvents - Ethanol | 5000 ppm max |
Applications
Sodium methotrexate is primarily used in pharmaceutical and clinical settings as a chemotherapeutic and immunosuppressive agent. It functions as an antimetabolite, inhibiting dihydrofolate reductase, which interferes with DNA synthesis, repair, and cellular replication. This mechanism makes it effective in treating various cancers, including leukemia, lymphoma, and solid tumors, as well as autoimmune conditions such as rheumatoid arthritis and psoriasis. In research, it is used to study folate metabolism, cell proliferation, and drug resistance mechanisms. The sodium salt form improves solubility and facilitates formulation for intravenous or oral administration in therapeutic applications.
Benefits
The benefits of Sodium methotrexate include its proven efficacy in controlling abnormal cell growth and modulating immune responses. Its solubility in water enhances bioavailability, enabling more precise dosing and consistent therapeutic effects. The compound's well-characterized pharmacological profile allows clinicians and researchers to predict and monitor its activity and toxicity. Additionally, its chemical stability in solution and compatibility with other pharmaceutical excipients support formulation into injectable or oral dosage forms, facilitating safe handling, storage, and administration.
Conclusion
Sodium methotrexate is a critical antimetabolite used in cancer therapy and autoimmune disease management. Its solubility, stability, and pharmacological effectiveness make it a reliable and widely used compound in both clinical and research settings. These properties ensure consistent therapeutic outcomes and support ongoing studies in drug development and disease treatment strategies.
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