CAS · 6638-79-5
Product Overview
N,O-Dimethylhydroxylamine hydrochloride丨6638-79-5 is a versatile methylating and aminating reagent commonly used in organic synthesis, pharmaceuticals, and agrochemicals. It is a valuable intermediate in amide bond formation, Weinreb amide synthesis, and oxidation reactions.
Product Specifications
| Property | Specification |
|---|---|
| Appearance | White to slightly white crystalline powder |
| Identification | Conforms |
| 10% Water Solution (DMHA:Water = 1:9) | Colorless transparent, no suspended matter, no impurities |
| Purity (Titration) | 98.5% min |
| Melting Point | 112~116°C |
| Water | 0.5% max |
Applications
1. Pharmaceutical Industry
● Weinreb Amide Formation:
Used to synthesize Weinreb amides, which are key intermediates in the preparation of ketones and aldehydes.
● API Development:
Serves as a building block in the synthesis of active pharmaceutical ingredients (APIs), particularly in the production of drugs with amide functional groups.
● Peptide and Protein Chemistry:
Used in amide bond formation during peptide synthesis.
2. Agrochemical and Fine Chemical Synthesis
● Intermediate for Pesticides and Herbicides:
Utilized in the synthesis of crop protection agents such as herbicides and fungicides.
3. Organic Synthesis & Material Science
● O-Methylation and N-Methylation Reactions:
Used as a methylating agent for oxygen and nitrogen-containing compounds.
● Oxidation Reactions and Radical Chemistry:
Plays a role in specific oxidation and radical-based transformations in organic chemistry.
Benefits
1. Key Reagent for Weinreb Amide Formation
● Enables highly selective ketone and aldehyde synthesis, crucial for pharmaceutical and fine chemical production.
2. Versatile Methylation Agent
● Used in N-methylation and O-methylation reactions, broadening its utility in organic synthesis.
3. Essential for Drug and Agrochemical Synthesis
● Integral in the production of pharmaceutical drugs and agrochemicals, enhancing its industrial significance.
Conclusion
N,O-Dimethylhydroxylamine hydrochloride丨6638-79-5 is a highly valuable synthetic reagent with applications in pharmaceuticals, agrochemicals, and organic synthesis. Its role in Weinreb amide formation, methylation reactions, and peptide synthesis makes it a crucial intermediate in drug discovery and fine chemical production.
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