CAS · 18342-66-0
Product Overview
N-Succinimidyl-N-methylcarbamate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off-white crystal powder |
|---|---|
| Purity (by HPLC) | 98% min |
| Loss on drying | 0.5% max |
| Melting point | 148–153 °C |
Applications
N-Succinimidyl-N-methylcarbamate is primarily used as a reactive intermediate and coupling reagent in organic synthesis, medicinal chemistry, and bioconjugation research. It is commonly employed for the introduction of N-methylcarbamoyl groups onto amines, alcohols, or other nucleophilic functional groups during multi-step synthesis. The activated succinimidyl ester functionality enables efficient and selective carbamoylation under mild conditions, making it useful in the preparation of pharmaceutical intermediates, protected amino compounds, and specialty fine chemicals. In biochemical research, it is also applied in modification and derivatization of small molecules to study structure–activity relationships and optimize molecular properties.
Benefits
This compound offers several advantages due to its activated ester structure and controlled reactivity. The succinimidyl leaving group provides high coupling efficiency and predictable reaction outcomes, reducing the need for harsh reaction conditions. The N-methylcarbamate moiety contributes stability while allowing precise functional group introduction, which is valuable in drug discovery and molecular design. Its relatively good solubility in common organic solvents facilitates handling and integration into diverse synthetic workflows. Additionally, the compound enables clean reactions with minimal by-product formation, supporting higher yields and simplified purification.
Conclusion
N-Succinimidyl-N-methylcarbamate is a valuable reagent for carbamoylation and functional group modification in organic and medicinal chemistry. Its applications in pharmaceutical intermediate synthesis and molecular derivatization, combined with benefits such as efficient coupling, mild reaction conditions, and synthetic versatility, make it an important tool for advanced chemical research and fine chemical production. The compound continues to support precise and efficient synthetic strategies across multiple research and industrial fields.
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