CAS · 498-94-2
Product Overview
Isonipecotic acid is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off-white crystalline powder |
|---|---|
| Identification | IR, NMR |
| Purity (HPLC) | 98% min |
| Melting point | ≥ 300 °C |
| Loss on drying | 1% max |
| Residue on ignition | 1% max |
Applications
Isonipecotic acid is a heterocyclic carboxylic acid with significant utility as a pharmaceutical intermediate and research tool. It is primarily employed in medicinal chemistry for the synthesis of drugs and experimental compounds that target the central nervous system, as its piperidine framework is a core structural motif in many bioactive molecules. It has been used in the preparation of anticonvulsants, neuroactive agents, and potential treatments for neurological disorders such as epilepsy and anxiety. In research, isonipecotic acid serves as a reference compound in pharmacological studies due to its activity as a GABA receptor agonist, making it valuable for investigating neurotransmission and receptor function. Additionally, it plays a role in fine chemical synthesis, where its versatile structure supports the creation of functional derivatives for both therapeutic and industrial applications.
Benefits
The benefits of isonipecotic acid stem from its pharmacological relevance and structural versatility. Its activity as a GABA receptor agonist provides researchers with a reliable compound for probing inhibitory neurotransmission, which is crucial for advancing understanding of brain function and neurological disease mechanisms. As a chemical building block, it facilitates the development of drug candidates with targeted bioactivity, especially within the central nervous system. Its stable and easily modifiable piperidine-carboxylic acid structure makes it a cost-effective and adaptable intermediate in pharmaceutical synthesis. Moreover, its dual role as both a research compound and a synthetic precursor highlights its value across both academic and industrial settings, supporting drug discovery efforts and the production of specialized chemicals.
Conclusion
Isonipecotic acid (CAS 498-94-2) is a valuable heterocyclic compound with important roles in pharmaceutical synthesis and neurological research. Its applications range from serving as an intermediate in drug development to functioning as a pharmacological tool for studying GABAergic neurotransmission. The compound's benefits lie in its structural adaptability, biological activity, and cost-effectiveness, making it indispensable for advancing both therapeutic innovation and fundamental neuroscience. Overall, isonipecotic acid continues to play a key role in bridging organic synthesis with biomedical research, particularly in the development and understanding of neuroactive compounds.
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