Ethyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
CAS 24683-26-9
CAS · 24683-26-9
Product Overview
Ethyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | almost white to yellow crystal powder |
|---|---|
| Purity: | 99% min |
| MP: | 140–143 deg C |
| Loss on drying: | 0.5% max |
| Single impurity: | 0.2% max |
| Total impurities: | 0.5% max |
Applications
1. Pharmaceutical Intermediate (NSAIDs)
Primarily used as an intermediate in the synthesis of Piroxicam, a widely used non-steroidal anti-inflammatory drug (NSAID).
Also relevant in the development of Lornoxicam, another NSAID in the oxicam class.
2. Medicinal Chemistry Research
The compound's benzothiazine core is useful in the synthesis of new drug candidates with anti-inflammatory, analgesic, and antipyretic activities.
Acts as a valuable building block for creating heterocyclic compounds with potential therapeutic effects.
3. Structure-Activity Relationship (SAR) Studies
Utilized in chemical biology and SAR studies to explore modifications on the oxicam scaffold to enhance pharmacokinetics or reduce side effects.
Benefits
🔬 Key Intermediate for Potent NSAIDs
Essential for manufacturing Piroxicam and its derivatives, which are long-acting and effective for treating chronic inflammatory conditions such as arthritis.
🏥 Clinical Relevance
Supports the production of drugs with proven efficacy in managing pain, inflammation, and fever, contributing to better patient outcomes.
🧪 Synthetic Versatility
The molecule features multiple reactive groups (hydroxy, ester, sulfone), allowing further functionalization in medicinal chemistry.
💊 Cost-Efficiency
Facilitates efficient and scalable synthesis routes for high-demand pharmaceutical agents.
Conclusion
Ethyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (CAS 24683-26-9) is a key pharmaceutical intermediate best known for its role in synthesizing NSAIDs like Piroxicam and Lornoxicam. Its complex heterocyclic structure makes it valuable in the design of new anti-inflammatory agents. The compound is widely used in both industrial drug manufacturing and academic research focused on novel therapeutic agents. As the demand for effective and safe anti-inflammatory drugs continues, this intermediate remains critical to pharmaceutical innovation.
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