Ethanol, 2-(3aR,4S,6R,6aS)-6-5-aMino-6-chloro-2-(propylthio)-4-pyriMidinylaMinotetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yloxy-
CAS 376608-74-1
CAS · 376608-74-1
Product Overview
Ethanol, 2-(3aR,4S,6R,6aS)-6-5-aMino-6-chloro-2-(propylthio)-4-pyriMidinylaMinotetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yloxy- is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to light pink solid |
|---|---|
| Identification (IR) | The infrared absorption spectrum of sample corresponds to that of reference substance |
| 152-99 | 0.15% max |
| Max unknown single impurity | 0.15% max |
| Total impurities | 1% max |
| Loss on drying | 2% max |
| Water | 1.5% max |
| Enantiomer | 0.1% max |
| Residue on ignition | 0.5% max |
| Assay (in terms of anhydrous) | 98% to 102% |
Applications
This compound is primarily used as a key intermediate in antiviral drug research and development. Its complex nucleoside-like structure makes it suitable for the synthesis of nucleoside analogues that can inhibit viral replication by targeting viral polymerases or interfering with nucleic acid synthesis. It is applied in medicinal chemistry to design and optimize antiviral therapeutics, particularly for RNA and DNA viruses. Additionally, the compound is used in biochemical research for studying enzyme interactions, prodrug strategies, and structure–activity relationships in nucleoside-based drug candidates. It also serves as a building block for the preparation of modified nucleotides and nucleoside derivatives for pharmacological evaluation.
Benefits
The compound offers several advantages due to its highly functionalized and stereochemically defined structure. Its multiple reactive groups, including amino, chloro, and propylthio substituents, allow for selective chemical modifications and derivatization, which is essential for designing potent and selective antiviral agents. The tetrahydrocyclopentane and dioxol moieties provide stability and rigidity, supporting metabolic resistance and improving pharmacokinetic properties in derivative compounds. Additionally, its stereochemical precision ensures reproducibility in synthetic and pharmacological studies, while the nucleoside-like framework facilitates incorporation into nucleic acid analogues for targeted biological activity.
Conclusion
Ethanol, 2-(3aR,4S,6R,6aS)-6-(5-amino-6-chloro-2-(propylthio)-4-pyrimidinylamino)tetrahydro-2,2-dimethyl-4H-cyclopenta[1,3]dioxol-4-yloxy) is a valuable intermediate in antiviral drug discovery and nucleoside analogue synthesis. Its applications in medicinal chemistry and biochemical research, combined with benefits such as structural stability, stereochemical precision, and versatile functionalization, make it a critical building block for developing novel antiviral therapeutics. The compound continues to support innovation in nucleoside-based drug development and advanced pharmacological studies.
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