1,1-Dimethylethyl N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)carbamate
CAS 247068-82-2
CAS · 247068-82-2
Product Overview
1,1-Dimethylethyl N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)carbamate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off-white solid |
|---|---|
| Purity | 99% min |
| Solubility | Soluble in dichloromethane and insoluble in water |
| HNMR | Conforms to structure |
| Related Substances - RR-isomer | 0.5% max |
| Related Substances - SS-isomer | 0.5% max |
| Related Substances - RS-isomer | 0.3% max |
| Water | 0.5% max |
Applications
1,1-Dimethylethyl N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)carbamate (CAS 247068-82-2) is a highly specialized intermediate used in the synthesis of chiral pharmaceuticals and bioactive molecules. Its structure combines a carbamate-protected amine with a stereochemically defined epoxide moiety, making it suitable for enantioselective transformations, nucleophilic ring-opening reactions, and multi-step organic synthesis. This compound is particularly valuable in medicinal chemistry for the preparation of amino alcohol derivatives, enzyme inhibitors, and peptide mimetics. Additionally, it is employed in structure–activity relationship (SAR) studies, allowing chemists to explore the effects of stereochemistry and functional group placement on biological activity.
Benefits
The benefits of this compound stem from its stereochemical precision, dual functionality, and chemical stability. The carbamate group provides protection of the amine, preventing undesired side reactions during complex synthetic sequences, while the epoxide moiety offers a reactive site for regio- and stereoselective nucleophilic additions. Its defined (1S,2R) stereochemistry ensures the correct three-dimensional orientation, which is critical for producing bioactive and enantiomerically pure molecules. The compound is also stable under standard storage and reaction conditions, making it practical for use in both laboratory-scale and industrial synthetic applications. Its dual functionality and versatility in derivatization allow for the construction of diverse, high-value intermediates in drug discovery and chemical research.
Conclusion
1,1-Dimethylethyl N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)carbamate is a versatile and highly functionalized intermediate essential for chiral synthesis and medicinal chemistry. Its combination of a protected amine, reactive epoxide, and precise stereochemistry enables selective transformations and the development of enantiomerically pure bioactive molecules. By facilitating the design and synthesis of complex pharmaceutical candidates, it remains a key tool in modern drug discovery and organic synthesis.
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