Boc-Arg(Pbf)-OH

Boc-Arg(Pbf)-OH is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

Boc-Arg(Pbf)-OH (CAS 200124-22-7) is a protected amino acid widely used in peptide synthesis and medicinal chemistry. It serves as a building block for the stepwise assembly of peptides via solid-phase or solution-phase synthesis. The Boc (tert-butoxycarbonyl) group protects the N-terminal amino group, while the Pbf (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl) group protects the guanidino side chain of arginine, preventing undesired side reactions during coupling steps. It is commonly employed in the synthesis of therapeutic peptides, enzyme inhibitors, and bioactive oligopeptides for pharmaceutical and biochemical research.

The benefits of Boc-Arg(Pbf)-OH stem from its high stability and selective protection strategy. The Boc group is acid-labile, allowing controlled deprotection under mild conditions, while the Pbf group is stable during peptide elongation but can be removed efficiently at the final stages. These protection features minimize side reactions and racemization, ensuring high-purity peptide products. Additionally, its solubility in common organic solvents and compatibility with various coupling reagents make it practical for both laboratory and industrial peptide synthesis.

Boc-Arg(Pbf)-OH is an essential protected amino acid intermediate in peptide synthesis. Its dual protection strategy, stability, and compatibility with standard coupling methods enable efficient and high-fidelity synthesis of arginine-containing peptides. By facilitating the production of therapeutic and bioactive peptides, it remains a vital tool in medicinal chemistry and biochemical research.

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