Alanine, 2-Methyl-, 1,1-diMethylethyl ester, hydrochloride

Alanine, 2-Methyl-, 1,1-diMethylethyl ester, hydrochloride is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

Alanine, 2-methyl-, 1,1-dimethylethyl ester, hydrochloride is commonly used as a protected form of L-valine in peptide synthesis, especially in solid-phase peptide synthesis (SPPS) and solution-phase assembly. The tert-butyl ester protects the carboxyl group, while the hydrochloride salt improves stability and handling, making the compound suitable for multi-step synthetic routes. It plays a key role in preparing bioactive peptides, enzyme substrates, peptidomimetics, and pharmaceutical intermediates where selective deprotection and efficient coupling are required. This reagent is also applied in combinatorial chemistry, structure–activity relationship studies, and the synthesis of modified amino acid derivatives that demand precise stereocontrol. In some cases, it is used as a precursor for producing specialty building blocks in medicinal chemistry research and fine chemical synthesis.

This compound provides several advantages due to its stability, ease of deprotection, and clean reaction behavior. The tert-butyl ester protecting group is resistant to many coupling conditions, allowing the amino acid to participate in peptide formation without undesired side reactions. At the same time, it can be removed efficiently under acidic conditions, enabling controlled stepwise synthesis. The hydrochloride form enhances solubility in certain polar solvents and provides improved shelf stability compared with the free amine. Its stereochemical purity supports high-fidelity peptide assembly, reducing racemization risks and ensuring reliable production of enantiomerically pure sequences. The compound is also easy to weigh, handle, and store, making it convenient for routine use in research laboratories and production environments.

Alanine, 2-Methyl-, 1,1-dimethylethyl ester, hydrochloride (CAS 84758-81-6) is a valuable protected amino acid derivative widely used in peptide synthesis and medicinal chemistry. Its stable tert-butyl ester protecting group and reliable stereochemistry make it suitable for constructing complex peptides and bioactive molecules with controlled selectivity. By offering good stability, clean deprotection behavior, and excellent compatibility with modern coupling strategies, it serves as an essential building block for developing high-quality peptide products and specialized synthetic intermediates.

Previous

3,5-Bis(trifluoromethyl)benzyl Alcohol丨CAS 32707-89-4

Next

4-Methylindole丨CAS 16096-32-5