6-Bromoimidazo[1,2-a]pyridin-8-amine

6-Bromoimidazo[1,2-a]pyridin-8-amine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Pharmaceutical Research and Development

Used as a building block in the synthesis of novel bioactive molecules.

The imidazo[1,2-a]pyridine scaffold is known for its presence in many drugs with diverse pharmacological activities including:

Antiviral

Antibacterial

Anticancer

CNS (central nervous system) agents

The bromine atom allows for cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira), facilitating the introduction of various substituents to optimize biological activity.

The amine group offers a site for further derivatization or conjugation.

2. Medicinal Chemistry

Enables the design and synthesis of compounds targeting kinases, receptors, and enzymes.

Used in lead optimization to improve potency, selectivity, and pharmacokinetic profiles.

3. Chemical Biology

Serves as a tool compound or intermediate in chemical probes development.

Can be incorporated into libraries for screening against biological targets.

✅ Versatile Synthetic Intermediate

The presence of bromine at the 6-position provides a reactive handle for palladium-catalyzed cross-coupling reactions.

The amine at position 8 allows for functionalization via acylation, alkylation, or other modifications.

✅ Pharmacologically Relevant Scaffold

Imidazo[1,2-a]pyridines are known for their drug-like properties including good bioavailability and metabolic stability.

The scaffold is privileged in medicinal chemistry, meaning it frequently leads to biologically active compounds.

✅ Facilitates Structure-Activity Relationship (SAR) Studies

Allows medicinal chemists to systematically vary substituents for optimizing efficacy and reducing toxicity.

6-Bromoimidazo[1,2-a]pyridin-8-amine (CAS 676371-00-9) is a valuable heterocyclic intermediate widely used in pharmaceutical synthesis and drug discovery. Its reactive bromine and amine groups make it highly versatile for chemical modification, enabling the development of diverse therapeutic agents with potential applications in antiviral, anticancer, and CNS disorders.

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