CAS · 64951-58-2
Product Overview
4-Chloro-8-methoxy-2-methylquinoline is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white to earth yellow solid |
|---|---|
| Purity (HPLC) | 97% min |
| Water | 0.5% max |
| 1H NMR | Conforms |
Applications
4-Chloro-8-methoxy-2-methylquinoline (CAS 64951-58-2) is a heterocyclic aromatic compound widely used as an intermediate in pharmaceutical and chemical research. In medicinal chemistry, it serves as a key building block for the synthesis of antimalarial, antiviral, and antibacterial agents, where the quinoline scaffold contributes to biological activity and target specificity. It is also employed in the development of fluorescent probes, dyes, and ligands for coordination chemistry due to its electron-rich aromatic system. Additionally, it acts as a precursor in the preparation of more complex quinoline derivatives, enabling structural modifications for optimizing pharmacokinetics and bioactivity.
Benefits
The benefits of 4-chloro-8-methoxy-2-methylquinoline stem from its multifunctional reactivity and stable quinoline core. The chloro substituent allows selective nucleophilic substitution or cross-coupling reactions, while the methoxy and methyl groups influence electronic properties and solubility, enhancing versatility in synthesis. Its rigid heteroaromatic structure provides steric and electronic stability, making it suitable for incorporation into bioactive molecules and functional materials. Additionally, its well-defined chemical profile ensures reproducibility in multi-step syntheses, facilitating rapid development of pharmaceutical or chemical derivatives.
Conclusion
In summary, 4-chloro-8-methoxy-2-methylquinoline is a versatile intermediate used in pharmaceuticals, fluorescent probe development, and heterocyclic synthesis. Its applications include drug development, dye and ligand preparation, and chemical research, while its benefits lie in selective reactivity, electronic stability, and structural versatility. With these properties, it remains an important building block for designing bioactive molecules and functional chemical compounds.
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