CAS · 1016234-87-9
Product Overview
4-Bromo-5-fluoro-2-nitrophenol is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White to off-white solid |
|---|---|
| Purity: | 97% min |
Applications
1. Pharmaceutical Intermediate
Used as a building block for synthesizing bioactive molecules and drug candidates.
The presence of halogens (bromo and fluoro) and nitro group allows for further functionalization such as nucleophilic substitution, reduction, or cross-coupling reactions.
Enables development of compounds with improved pharmacokinetic properties, binding affinity, and metabolic stability.
2. Agrochemical Synthesis
Acts as an intermediate in manufacturing herbicides, fungicides, and insecticides.
The reactive groups facilitate modifications to optimize bioactivity and environmental profiles.
3. Organic Chemistry Research
Used in method development for selective substitution reactions, cross-coupling (e.g., Suzuki, Heck), and functional group interconversions.
Serves as a model compound for studying reactivity of halogenated nitrophenols.
Benefits
✅ Highly Functionalized Intermediate
Multiple reactive sites enable versatile synthetic routes.
The combination of bromine and fluorine atoms provides opportunities for regioselective and chemoselective reactions.
✅ Facilitates Medicinal Chemistry Optimization
Halogen substituents can significantly enhance lipophilicity, binding interactions, and metabolic resistance of target molecules.
✅ Versatile Synthetic Utility
Nitro group can be reduced to amines for further derivatization.
Phenol hydroxyl can be modified or protected depending on synthetic needs.
Conclusion
4-Bromo-5-fluoro-2-nitrophenol (CAS 1016234-87-9) is a valuable halogenated phenolic intermediate widely used in the synthesis of pharmaceuticals and agrochemicals. Its multifunctional nature allows for diverse chemical transformations, making it essential for developing advanced bioactive compounds with optimized properties.
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