CAS · 120-20-7
Product Overview
3,4-Dimethoxyphenethylamine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Item | Specification |
|---|---|
| Appearance | Colorless to light yellow transparent liquid |
| Purity | 98.0% min |
| Identification | HPLC |
| Single impurity | 0.5% max |
| Total impurity | 2.0% max |
| Water | 0.5% max |
Applications
3,4-Dimethoxyphenethylamine (CAS 120-20-7), also known as homoveratrylamine, is an aromatic amine used as an intermediate in pharmaceuticals, agrochemicals, and fine chemical synthesis. In medicinal chemistry, it is applied in the preparation of bioactive compounds, including sympathomimetic agents, enzyme inhibitors, and central nervous system–active molecules. It also serves as a precursor in the synthesis of alkaloids, indole derivatives, and other heterocycles where the 3,4-dimethoxyphenyl group contributes to binding affinity and metabolic stability. In research, it is employed in structure–activity relationship (SAR) studies as a model phenethylamine derivative. Additionally, it is used in chemical biology and organic synthesis as a versatile scaffold for generating libraries of substituted amines and functionalized aromatic compounds.
Benefits
The benefits of 3,4-dimethoxyphenethylamine derive from its balanced structure and reactivity. The phenethylamine backbone provides a flexible and biologically relevant scaffold for drug discovery, while the methoxy substituents enhance lipophilicity, modulate electronic properties, and improve metabolic stability. The primary amine allows for straightforward transformations such as acylation, alkylation, reductive amination, or coupling, making it adaptable for diverse synthetic pathways. Its dual functionalization-aromatic substitution and reactive amine-enables chemists to efficiently construct complex molecules with tailored pharmacological or chemical properties.
Conclusion
In summary, 3,4-dimethoxyphenethylamine is a multifunctional intermediate with applications in pharmaceuticals, fine chemicals, and organic synthesis. Its uses range from drug and alkaloid synthesis to SAR studies, while its benefits lie in scaffold flexibility, favorable lipophilic and electronic characteristics, and synthetic versatility. As demand for functionalized phenethylamine derivatives continues to grow, this compound remains a valuable building block for research and development in medicinal and chemical sciences.
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