CAS · 57090-45-6
Product Overview
(R)-(-)-3-Chloro-1,2-propanediol is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Clear to pale yellow liquid |
|---|---|
| Assay (GC) | 98% min |
| Enantiomeric Excess | 99% min |
| Optical Rotation [α]D20 | -1° to -1.4° |
| Water | 0.5% max |
Applications
(R)-(-)-3-Chloro-1,2-propanediol is a chiral chlorohydrin widely used as an intermediate in pharmaceutical, chemical, and fine chemical synthesis. It serves as a building block for the preparation of epichlorohydrin, chiral glycidyl ethers, and other epoxide derivatives, which are key intermediates in drug synthesis and asymmetric catalysis. In medicinal chemistry, it is employed in the production of antiviral agents, antihypertensive drugs, and other bioactive molecules that require stereochemically defined intermediates. Additionally, it finds applications in the synthesis of surfactants, polymeric materials, and functionalized chemicals, where its reactive chlorine and hydroxyl groups allow for versatile chemical transformations.
Benefits
The benefits of (R)-(-)-3-chloro-1,2-propanediol arise from its chirality, bifunctional reactivity, and chemical stability. The (R)-configuration provides enantiomeric purity, which is essential for synthesizing stereochemically defined compounds with predictable biological activity. Its hydroxyl and chloro groups enable selective functionalization, allowing efficient conversion to epoxides, ethers, and other derivatives. The compound is compatible with a variety of solvents and reaction conditions, making it versatile for both laboratory-scale and industrial synthesis. These properties support high yields, reproducibility, and process efficiency in pharmaceutical and chemical manufacturing.
Conclusion
In summary, (R)-(-)-3-chloro-1,2-propanediol is a chiral intermediate with applications in pharmaceuticals, asymmetric synthesis, and polymer chemistry. Its benefits include enantiomeric purity, bifunctional reactivity, chemical stability, and versatility for complex organic transformations. By combining stereochemical precision with synthetic utility, this compound continues to be an essential building block in drug development and advanced chemical synthesis.
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