CAS · 9002-96-4
Product Overview
Tocofersolan is a high-purity pharmaceutical-excipients supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | USP43 |
|---|---|
| Appearance | Off-white or yellowish waxy solid |
| Identification | Meets the requirements |
| Assay (D-α-tocopherol) | 26.0% min. |
| Solubility in water | 20% min (Clear solution within 3h) |
| Acidity | 0.27 mL max. |
| Monoesterified Polyethylene glycol | 65.0% min. |
| Polyethylene glycol | 23.0% max. |
| Vitamin E succinate | 0.2% max. |
| Vitamin E | 1.5% max. |
| Specific Rotation | +24.0° min. |
| Heavy metals | 10 ppm max. |
| Cadmium | 1 ppm max. |
| Arsenic | 1 ppm max. |
| Lead | 3 ppm max. |
| Mercury | 0.1 ppm max. |
| Ethyl acetate | 50 ppm max. |
| Ethanol | 200 ppm max. |
| Total Plate Count (Aerobic bacteria) | 1000 CFU/g max. |
| Yeast & Mold | 100 CFU/g max. |
| Salmonella | Negative |
| E. Coli | Negative |
Applications
Tocofersolan (CAS 9002-96-4), also known as water-soluble vitamin E derivative, is primarily used in pharmaceutical, nutraceutical, and cosmetic applications. Its main application is as a delivery form of vitamin E (tocopherol) that is soluble in water, allowing for enhanced bioavailability in oral, parenteral, and topical formulations. In pharmaceuticals, Tocofersolan is used to prevent or treat vitamin E deficiency, especially in patients with fat malabsorption disorders such as cystic fibrosis, cholestatic liver disease, or short bowel syndrome. In the nutraceutical industry, it is incorporated into functional foods, beverages, and dietary supplements to support antioxidant protection, immune function, and overall cellular health. In cosmetics, it is used in creams, lotions, and serums to provide antioxidant benefits, helping protect skin from oxidative stress and premature aging.
Benefits
The benefits of Tocofersolan stem from its enhanced solubility, stability, and bioavailability compared to standard fat-soluble vitamin E. Its water-soluble form allows for rapid absorption in individuals who cannot efficiently metabolize fat-soluble vitamins, ensuring effective supplementation and therapeutic outcomes. As an antioxidant, it helps protect cell membranes from lipid peroxidation, reducing oxidative damage and supporting overall cellular function. In dermatological applications, it contributes to skin protection, hydration, and repair, improving skin health and appearance. Its compatibility with both water- and lipid-based formulations also provides formulators with flexibility, enabling the incorporation of vitamin E into a wide variety of delivery systems without compromising efficacy.
Conclusion
In conclusion, Tocofersolan is a valuable vitamin E derivative with applications in pharmaceuticals, nutraceuticals, and cosmetics. Its water-soluble nature, enhanced bioavailability, and antioxidant properties make it particularly beneficial for individuals with fat absorption issues, as well as for skin and general health protection. By combining effectiveness, versatility, and functional benefits, Tocofersolan continues to be an important ingredient in modern health, wellness, and personal care products.
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