CAS · 99241-25-5
Product Overview
gamma-Cyclodextrin-2-hydroxypropyl ether is a high-purity cyclodextrin-derivatives supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White or almost white powder; Odorless, slightly sweet; Freely soluble in water, soluble in ethanol, almost insoluble in acetone. |
|---|---|
| Assay: | 98.0% min |
| Water solution pH: | 5.0 to 8.5 |
| Light-absorbing impurities: | Between 230 and 350 nm, the absorbance is NMT 0.5; Between 350 and 660 nm, the absorbance is NMT 0.5 |
| Water content: | 10.0% max |
| Gamma Cyclodextrin: | 1.5% max |
| Residue on ignition: | 0.2% max |
| Heavy metal: | 10 ppm max |
| Propylene glycol: | 0.5% max |
| Hydroxypropoxyl content: | 17.5% to 29.1% |
| Total aerobic microbial count: | 1000 cfu/g max |
| Total combined moulds and yeasts count: | 100 cfu/g max |
| Escherichia coli: | Absence |
| Bacterial Endotoxins Test: | According to preparation needs |
Applications
1. Pharmaceutical and Biotech Fields
Solubilizing Agent: Improves the solubility and bioavailability of poorly water-soluble drugs (e.g., steroids, antifungals, and anticancer drugs).
Stabilizer: Prevents degradation of sensitive APIs by shielding them from light, oxygen, or heat.
Formulation Enhancer: Used in injectable, oral, nasal, and ophthalmic drug delivery systems.
Gene and Protein Delivery: Investigated as a non-viral vector for delivering nucleic acids and therapeutic proteins.
2. Cosmetics and Personal Care
Fragrance Delivery: Sustained and controlled release of volatile aromatic compounds in perfumes and skincare products.
Stabilization of Actives: Protects labile ingredients like vitamins and antioxidants from degradation.
Skin- and Hair-Friendly Base: Enhances absorption and aesthetic feel in creams and serums.
3. Food and Nutrition
Flavor Encapsulation: Enhances flavor stability and release in beverages, chewing gums, and snacks.
Cholesterol Removal: Binds and reduces cholesterol in dairy and egg-based products.
Preservation Aid: Encapsulates sensitive nutrients or flavorants to prevent premature degradation.
4. Industrial and Environmental Uses
Water Treatment: Captures hydrophobic pollutants from aqueous environments due to inclusion capabilities.
Analytical Chemistry: Used to increase the resolution of enantiomeric separations in chromatography.
Smart Materials: Incorporated into polymers or films for slow-release or responsive systems.
Benefits
Feature
Benefit
High aqueous solubility
Superior to native γ-CD, enabling broader applications
Larger cavity size (~0.95 nm)
Accommodates larger guest molecules (e.g., steroids, antibiotics)
Low toxicity and non-irritating
Safe for pharmaceutical and personal care use
Biodegradable and biocompatible
Suitable for human use and environmental applications
Controlled substitution
Tailorable properties based on hydroxypropylation degree
Conclusion
gamma-Cyclodextrin-2-hydroxypropyl ether丨CAS 99241-25-5 is a versatile, water-soluble cyclodextrin derivative with excellent complexation ability and safety. It plays a vital role in drug solubilization, delivery, stabilization, and controlled release, as well as in cosmetics, food science, and environmental protection. Its broad cavity size and hydroxypropyl modifications make it uniquely suited for accommodating larger or bulkier hydrophobic compounds where native cyclodextrins fall short.
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