CAS · 1310726-60-3
Product Overview
Upadacitinib is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White, off-white to yellow to brown solid |
|---|---|
| Identification by NMR | The test sample is consistent with the nuclear magnetic resonance (NMR) of the test sample |
| Related Substances by HPLC | Purity 99.0% min |
| Any Single Impurity | 0.5% max |
| Assay on Dried Basis (w/w) | 98.0% min |
| Water Content by KF | 3.0% max |
| Residue on Ignition | 0.20% max |
| Heavy Metals | 10 ppm max |
Applications
1. Therapeutic Use
a. Rheumatoid Arthritis (RA)
● Approved as a monotherapy or in combination with methotrexate for adults with moderate to severe RA who have had an inadequate response to TNF blockers or other DMARDs.
b. Psoriatic Arthritis (PsA)
● Treats active PsA in patients unresponsive to conventional therapies or biologics.
c. Atopic Dermatitis
● Approved for moderate to severe atopic dermatitis, particularly in adults and adolescents (12 years and older) who are not adequately controlled with topical medications.
d. Ulcerative Colitis (UC)
● Used for moderate to severe UC as an oral alternative to corticosteroids and biologics.
e. Ankylosing Spondylitis & Axial Spondyloarthritis
● Indicated for adults with active ankylosing spondylitis or non-radiographic axial spondyloarthritis.
Benefits
1. Targeted Immunomodulation
● Offers precise control of immune signaling pathways, reducing inflammation while preserving broader immune function.
2. Oral Administration
● Taken once daily as an oral tablet, providing a convenient alternative to injectable biologics like TNF inhibitors.
3. Rapid Onset of Action
● Clinical studies show symptom relief within weeks, making it suitable for patients requiring quick therapeutic impact.
4. Wide Indication Spectrum
● Approved across multiple chronic autoimmune diseases, reducing the need for multiple medications in comorbid conditions.
Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.