CAS · 1369852-71-0
Product Overview
Lotilaner is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White or off-white powder |
|---|---|
| Assay | 98.0% to 102.0% |
| NMR | Match with Structure |
| MS | [M+H], [M+NH4], [M+Na], [M-H], [M-H+H2O] |
| Single impurity | 0.1% max |
| Total impurities | 0.5% max |
| R-isomer | 0.2% max |
| Residue of solvents - n-Heptane | 0.5% max |
| Residue of solvents - Methylene dichloride | 0.06% max |
| Residue of solvents - Ethanol | 0.5% max |
| Residue of solvents - Acetonitrile | 0.041% max |
| Residue of solvents - Ethyl acetate | 0.5% max |
| Residue of solvents - Tetrahydrofuran | 0.072% max |
| Residue of solvents - Triethylamine | 0.5% max |
| Water | 1.0% max |
| Residue on ignition | 0.1% max |
Applications
Lotilaner (CAS 1369852-71-0) is a potent ectoparasiticide widely used in veterinary medicine for the treatment and prevention of flea and tick infestations in companion animals. Its primary applications include oral and topical formulations for dogs and cats, where it targets adult and immature stages of fleas and various tick species. Lotilaner belongs to the isoxazoline class of compounds, which act by inhibiting gamma-aminobutyric acid (GABA)-gated chloride channels in parasites, leading to hyperexcitation and death. Its rapid onset of action and long-lasting efficacy make it suitable for monthly dosing regimens, providing effective parasite control and improving animal health.
Benefits
The benefits of Lotilaner stem from its high efficacy, safety profile, and convenience of use. It provides rapid flea and tick elimination, reducing the risk of parasite-borne diseases and improving the well-being of pets. Its selective mode of action ensures minimal toxicity to mammals while being highly lethal to ectoparasites. Additionally, its oral bioavailability and sustained activity allow for consistent monthly protection, enhancing compliance and ease of administration for pet owners. Lotilaner's stability and compatibility with veterinary formulations make it a reliable and practical choice for routine parasite management.
Conclusion
In conclusion, Lotilaner is an effective and safe ectoparasiticide for dogs and cats, offering rapid, long-lasting protection against fleas and ticks. Its potent activity, selective mechanism, and convenient dosing support animal health and parasite control. By enabling reliable and efficient management of infestations, Lotilaner plays a vital role in modern veterinary therapeutics.
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