CAS · 50-03-3
Product Overview
Hydrocortisone acetate is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | EP9.8 |
|---|---|
| Appearance | White to off-white crystalline powder |
| Solubility | Practically insoluble in water, slightly soluble in anhydrous ethanol and methylene chloride |
| Identification | IR spectrum: Matches hydrocortisone acetate CRS spectrum HPLC: Principal peak retention time and size similar to reference |
| Specific Optical Rotation | +158° to +167° (dried substance) |
| Related Substances (Impurities) | Impurity A (RRT 0.4): ≤ 0.5% Impurity B (RRT 0.7): ≤ 0.3% Impurity C (RRT 0.9): ≤ 0.6% Impurity D (RRT 1.2): ≤ 0.3% Impurity G (RRT 1.8): ≤ 0.15% Impurity E (RRT 2.3): ≤ 0.3% Any unspecified impurity: ≤ 0.10% Total impurities: ≤ 1.5% |
| Loss on Drying | ≤ 0.5% |
| Assay (dried substance) | 97.0% to 102.0% |
| Residual Solvents (In-house) | Methanol: ≤ 3000 ppm Ethanol: ≤ 2000 ppm Acetone: ≤ 5000 ppm Methylene chloride: ≤ 600 ppm DMF: ≤ 880 ppm |
| Particle Size (In-house) | 90% ≤ 20 microns |
Applications
1. Anti-inflammatory Agent
Hydrocortisone acetate丨CAS 50-03-3 is widely used in topical formulations (creams, ointments, lotions) for treating inflammatory skin conditions such as eczema, psoriasis, dermatitis, and allergic reactions.
It works by suppressing the immune response and reducing inflammation, redness, and swelling.
2. Endocrine Disorders Treatment
Used in oral or injectable forms to replace cortisol in patients with adrenal insufficiency or Addison's disease.
Helps regulate metabolism, immune response, and stress adaptation.
3. Allergic Conditions
Effective in managing allergic reactions involving the skin and mucous membranes, such as urticaria and contact dermatitis.
Reduces itching and discomfort caused by allergies.
4. Respiratory and Autoimmune Diseases
Employed as part of therapy for certain autoimmune diseases and respiratory conditions where inflammation control is critical, such as asthma or rheumatoid arthritis (often in systemic forms).
5. Ophthalmic and Otic Preparations
Used in certain eye drops and ear drops to treat inflammation and allergic conditions of the eyes and ears.
Benefits
1. Potent Anti-inflammatory Effect
Hydrocortisone acetate is a potent glucocorticoid, offering strong suppression of inflammatory pathways through inhibition of pro-inflammatory cytokines and immune cell activity.
2. Improved Stability and Duration
The acetate ester modification enhances stability and prolongs the duration of action compared to hydrocortisone itself, making it suitable for topical and systemic use.
3. Versatile Routes of Administration
Available in various dosage forms-topical, oral, injectable, ophthalmic, and otic-allowing treatment tailored to different conditions.
4. Well-Established Safety Profile
Hydrocortisone acetate has been used clinically for decades with a well-documented safety and efficacy profile when used appropriately.
Conclusion
Hydrocortisone acetate丨CAS 50-03-3 is a widely utilized glucocorticoid corticosteroid with diverse medical applications, particularly for anti-inflammatory and immunosuppressive therapy. Its enhanced stability and varied administration routes make it invaluable in managing dermatological, endocrine, allergic, and autoimmune disorders. It remains a cornerstone treatment in both topical and systemic corticosteroid therapy due to its effectiveness and established safety.
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