CAS · 385769-84-6
Product Overview
Amino Tadalafil is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White to off-white powder |
|---|---|
| Purity (HPLC): | 98% min |
| Solubility: | Soluble in ethanol, slightly soluble in water |
| Specific rotation: | +78° ～ +84° |
| 1H NMR: | Conforms to structure |
| HPLC: | The retention time of the test solution and reference solution should be consistent |
| Loss on drying: | 0.5% max |
| Sulphated ash: | 0.1% max |
Applications
Amino Tadalafil is an important pharmaceutical intermediate primarily used in the synthesis and structural modification of Tadalafil, a well-known phosphodiesterase type 5 (PDE5) inhibitor employed in the treatment of erectile dysfunction, pulmonary arterial hypertension, and benign prostatic hyperplasia. It serves as a key building block in medicinal chemistry research for developing new PDE5 inhibitor analogs with improved pharmacological profiles, such as enhanced bioavailability, selectivity, or reduced side effects. Beyond its pharmaceutical significance, it is also utilized in chemical synthesis studies involving heterocyclic modification, chiral drug design, and structure–activity relationship (SAR) analysis, aiding in the discovery of next-generation therapeutic agents targeting cardiovascular and urogenital systems.
Benefits
Amino Tadalafil offers excellent synthetic versatility, enabling efficient coupling and derivatization reactions due to the presence of its reactive amino functionality. Its structural similarity to the parent Tadalafil molecule makes it an ideal intermediate for generating high-purity derivatives with predictable biological activities. The compound exhibits high chemical stability, purity, and consistent performance in both laboratory and industrial-scale synthesis. Its use facilitates cost-effective and reproducible production of Tadalafil-related compounds, thereby supporting innovation in pharmaceutical development and generic formulation.
Conclusion
Amino Tadalafil is a crucial intermediate in the pharmaceutical industry, providing a reliable pathway for the synthesis and modification of PDE5 inhibitors. Its favorable reactivity, stability, and structural relevance make it indispensable for medicinal chemistry research and large-scale production of therapeutically important compounds, contributing to advancements in cardiovascular and reproductive health treatments.
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