CAS · 10238-21-8
Product Overview
Glyburide is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade: | EP 9 |
|---|---|
| Appearance: | A white or almost white crystalline powder |
| Assay (HPLC): | 98% to 102% |
| Solubility: | Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96%) and in methanol |
| Identification: | IR; HPLC conforms |
| Loss on drying: | 1.0% max |
| Residue on ignition: | 0.5% max |
| Related substance: | |
| Impurity A: | 1.5% max |
| Impurity C: | 0.5% max |
| Any other impurity: | 0.5% max |
| Total impurities: | 2% max |
Applications
1. Treatment of Type 2 Diabetes Mellitus (T2DM)
Glyburide is widely used to manage blood glucose levels in adults with type 2 diabetes, especially when diet, exercise, and weight reduction alone are not sufficient.
Monotherapy: Used alone to stimulate insulin secretion from the pancreas.
Combination Therapy: Often combined with other antidiabetic agents like metformin, DPP-4 inhibitors, or insulin to achieve better glycemic control.
2. Off-Label Uses
Though not routinely recommended, glyburide has been studied for other uses:
Gestational Diabetes Mellitus (GDM): Sometimes used off-label as an alternative to insulin in managing blood glucose during pregnancy. However, this use is controversial due to concerns about fetal exposure.
Neonatal Diabetes: In very rare genetic forms of diabetes in newborns (e.g., KATP channel mutations), glyburide may be used in specific clinical settings.
Benefits
1. Effective Glycemic Control
Glyburide significantly reduces both fasting and postprandial blood glucose levels.
Helps lower HbA1c (glycated hemoglobin), which reflects long-term glycemic control.
2. Once or Twice-Daily Dosing
Due to its relatively long half-life and high potency, glyburide can be dosed once or twice a day, improving patient adherence compared to drugs requiring multiple daily doses.
3. Cost-Effective
Glyburide is available in generic form, making it a low-cost option for managing type 2 diabetes, especially in resource-limited settings.
4. Complementary with Other Therapies
Can be used alongside other oral antidiabetic drugs or insulin, providing a flexible approach to treatment intensification when monotherapy is insufficient.
5. Long Clinical History
Glyburide has been used since the 1960s and is well-studied, with a comprehensive understanding of its risks, benefits, and clinical use.
Conclusion
Glyburide is a well-established oral antidiabetic agent in the sulfonylurea class, valued for its potent glucose-lowering effects and affordability. It plays a critical role in the management of type 2 diabetes, particularly in patients who are unable to achieve glycemic targets with lifestyle modifications alone. Its ability to stimulate insulin secretion makes it effective, especially in the earlier stages of diabetes when pancreatic β-cell function is still preserved. While it offers significant benefits, careful monitoring is essential due to the risk of hypoglycemia and weight gain. Overall, Glyburide remains an important tool in the diabetic therapeutic arsenal, especially in settings where cost-effective and proven treatment options are essential.
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