CAS · 152-11-4
Product Overview
(+/-)-Verapamil hydrochloride is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White or off-white solid |
|---|---|
| Purity (HPLC) | 99% min. |
| Identification | UV/NMR/HPLC |
| Loss on drying | 1.0% max. |
Applications
(+/-)-Verapamil hydrochloride is primarily used in the pharmaceutical industry as a calcium channel blocker for the treatment of cardiovascular conditions. It is commonly applied in managing hypertension, angina pectoris, and certain arrhythmias by inhibiting calcium ion influx in cardiac and vascular smooth muscle cells. In research, the compound is used to study calcium-dependent physiological processes, drug interactions, and pharmacokinetics of calcium channel modulators. It is also employed as a reference standard in analytical chemistry and quality control laboratories for the development and validation of pharmaceutical assays.
Benefits
(+/-)-Verapamil hydrochloride offers several advantages in therapeutic and research applications. Its ability to selectively block L-type calcium channels allows effective regulation of heart rate, cardiac contractility, and vascular tone, contributing to improved cardiovascular outcomes. The hydrochloride salt form enhances solubility and bioavailability, facilitating oral or injectable administration. Its well-characterized pharmacological profile ensures predictable therapeutic effects and reproducibility in both clinical and experimental settings. Additionally, it provides a reliable tool in research for probing calcium-mediated cellular mechanisms and evaluating drug efficacy in cardiovascular studies.
Conclusion
(+/-)-Verapamil hydrochloride is a widely used calcium channel blocker with applications in cardiovascular therapy, pharmacological research, and analytical studies. Its selective activity, solubility, and well-established efficacy make it valuable in both clinical and research contexts. Overall, (+/-)-Verapamil hydrochloride supports effective cardiovascular treatment, mechanistic studies of calcium signaling, and the development of pharmaceutical quality control methods.
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