CAS · 124832-27-5
Product Overview
Valacyclovir hydrochloride is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | USP Grade |
|---|---|
| Characteristics | White or almost white, crystalline powder |
| Assay | 98.0% to 102.0% |
| Identification | IR: The IR spectrum is concordant with the reference spectrum of valacyclovir hydrochloride Chlorides reaction: The aqueous solution yields the reactions characteristic of chlorides HPLC: According to the chromatogram recorded in the Assay item, the retention time of the major peak of test solution corresponds to the retention time of the major peak of reference solution |
| Related substances (by HPLC) | Any other individual impurity: 0.1% max Total unspecified Impurities: 0.2% max Guanine & Acyclovir: 2.0% max Related Compound A: 0.2% max D-Valacyclovir: 3.0% max Total Impurities: 5.0% max |
| Water | 5.0% to 9.0% |
| Residue on ignition | 0.1% max |
| Heavy Metals | 20 ppm max |
| Specific optical rotation [α]D25 | -8.5° to -11.5° |
| pH | 4.0 to 6.0 |
| Specific absorption index | From 336~372 at 254 nm (on anhydrous and organic solventless basis) |
| Residual solvents | Ethanol: 5000 ppm max Dimethyl formamide: 880 ppm max |
Applications
Valacyclovir hydrochloride is primarily used as an antiviral pharmaceutical for the treatment and management of viral infections caused by herpes viruses. It is commonly prescribed for conditions such as herpes simplex virus (HSV) infections, including genital herpes, cold sores, and shingles (herpes zoster). The compound is also used in prophylactic therapy to reduce the frequency and severity of recurrent outbreaks in patients with chronic herpes infections. In addition, Valacyclovir hydrochloride is applied in research to study antiviral mechanisms, pharmacokinetics, and the development of new nucleoside analogues with improved efficacy and bioavailability.
Benefits
Valacyclovir hydrochloride offers several advantages due to its chemical structure and pharmacological properties. As a prodrug of acyclovir, it provides significantly improved oral bioavailability, allowing effective systemic antiviral activity at lower doses compared to acyclovir. The compound selectively inhibits viral DNA polymerase, preventing viral replication while exhibiting low toxicity to host cells. Its stability, solubility, and ease of formulation make it suitable for oral administration in tablets or capsules. Additionally, it provides consistent therapeutic effects with a convenient dosing regimen, improving patient compliance and treatment outcomes.
Conclusion
Valacyclovir hydrochloride is a highly effective antiviral agent with broad applications in the treatment and management of herpes virus infections. Its use in clinical therapy, combined with benefits such as enhanced bioavailability, selective antiviral activity, and patient-friendly dosing, makes it an essential drug in modern antiviral medicine. The compound continues to support effective viral infection management and research into nucleoside-based therapeutics.
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