CAS · 1508-75-4
Product Overview
Tropicamide is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | EP8.0 |
|---|---|
| Appearance | A white or almost white, crystalline powder; slightly soluble in water, freely soluble in alcohol and methylene chloride |
| Melting point | 95–98℃ |
| Appearance of solution | 0.1 g of sample in 10 mL of alcohol is clear and colourless |
| Optical rotation | -0.1 to +0.1° |
| Related substances - Impurity A | 0.15% max |
| Related substances - Impurity B | 0.3% max |
| Related substances - Impurity C | 0.15% max |
| Related substances - Impurity D | 0.15% max |
| Unspecified impurity | 0.1% max |
| Sum of impurities other than C and D | 0.5% max |
| Loss on drying | 0.5% max |
| Assay (on dried basis) | 99%–101% (C17H20N2O2) |
Applications
Tropicamide (CAS 1508-75-4) is a widely used anticholinergic agent in ophthalmology. Its primary application is as a mydriatic and cycloplegic drug to dilate the pupil and temporarily paralyze the ciliary muscle, facilitating detailed examination of the retina, lens, and anterior chamber during diagnostic procedures. It is commonly used in eye exams, fundus photography, and preoperative procedures. Tropicamide is also employed in certain research settings for studying ocular pharmacology, pupil response, and autonomic nervous system function. Its short duration of action compared with other mydriatics makes it particularly useful for routine clinical examinations.
Benefits
The benefits of tropicamide lie in its rapid onset, short duration, and predictable pharmacological profile. Its mydriatic effect occurs within 15–30 minutes, allowing quick and efficient eye examinations, while cycloplegia typically lasts only a few hours, minimizing patient discomfort and reducing post-procedure visual impairment. Tropicamide has a favorable safety profile, with lower systemic absorption and reduced side effects compared with longer-acting anticholinergics. Its selectivity and reversibility make it convenient for repeated use in both adults and pediatric patients. These characteristics enhance its utility in clinical practice, supporting safe, effective, and patient-friendly ocular examinations.
Conclusion
In summary, tropicamide is an essential ophthalmic agent used primarily for pupil dilation and cycloplegia during diagnostic procedures. Its applications include routine eye exams, retinal imaging, and research on ocular pharmacology, while its benefits include rapid onset, short duration, safety, and predictable effect. With its practical advantages, tropicamide remains a preferred choice for ophthalmologists seeking efficient and reliable mydriatic and cycloplegic agents.
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