CAS · 13647-35-3
Product Overview
Trilostane is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to pale white solid |
|---|---|
| Assay | 99.0% min |
| Identification | IR absorption spectrum of the test sample complies with the spectrum of RS |
| Specific optical rotation | +137° to +139° |
| Loss on drying | 0.5% max |
| Heavy metals | 20 ppm max |
| Water (K.F) | 0.5% max |
| Tetrahydrofuran | 0.072% max |
| Tert-butyl methyl ether | 0.50% max |
| Ethanol | 0.50% max |
| Dimethyl sulfoxide | 0.50% max |
| Dichloromethane | 0.060% max |
| Residue on ignition | 0.1% max |
| Single impurity | 0.3% max |
| Storage conditions | Store in a cool place. Keep container tightly closed in a dry and well-ventilated place |
Applications
Trilostane is a synthetic steroidal compound widely used in pharmaceutical research, veterinary medicine, and endocrine studies. It is primarily applied in the treatment and management of hyperadrenocorticism in animals, particularly in canine patients, where it helps regulate excessive cortisol production. In veterinary formulations, trilostane is used in oral dosage forms designed for controlled and consistent hormone modulation. In biomedical and pharmacological research, it serves as a tool compound for studying steroid biosynthesis, adrenal function, and endocrine feedback mechanisms. Trilostane is also utilized in drug development programs focused on adrenal enzyme inhibitors and hormone-related disorders, supporting the screening and optimization of new therapeutic candidates. In analytical laboratories, it is applied as a reference standard for quality control, stability testing, and method validation in pharmaceutical analysis.
Benefits
The benefits of trilostane are closely linked to its targeted mechanism of action, established efficacy, and predictable pharmacological profile. It selectively inhibits 3β-hydroxysteroid dehydrogenase, an enzyme involved in cortisol and aldosterone synthesis, enabling controlled reduction of excessive steroid hormone production. This targeted inhibition helps minimize systemic side effects compared to broader-acting steroid suppressants. Trilostane demonstrates good oral bioavailability and consistent performance in approved veterinary dosage forms, supporting reliable long-term treatment regimens. Its chemical stability and well-defined purity specifications allow reproducible formulation and analytical testing. In research settings, trilostane provides a validated model compound for investigating adrenal disorders and evaluating endocrine-modulating agents.
Conclusion
Trilostane is an important steroidal inhibitor with significant value in veterinary medicine, endocrine research, and pharmaceutical development. Its selective suppression of steroid biosynthesis, combined with stable formulation characteristics and reliable performance, makes it a key compound for managing hormone-related conditions and supporting drug discovery efforts. By enabling precise control of cortisol production and advancing endocrine research, trilostane continues to play a vital role in modern veterinary and biomedical applications.
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