CAS · 602-41-5
Product Overview
Thiocolchicoside is a high-purity plant-extracts-natural-products supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Description | Pale yellow to crystalline powder |
|---|---|
| Assay (By HPLC) | 98.0%–102% (on dried basis) |
| Solubility | Soluble in water, slightly soluble in alcohol, insoluble in ether and acetone |
| Identification - IR | IR spectra should match with that of standard |
| Identification - UV | Absorbance maxima between 220–440 nm, corresponding with that of standard |
| pH (0.5% w/v sol. in water) | 6.0–7.5 |
| Specific Optical Rotation (0.5% sol. at 23℃ in water) | (-)550° to (-)580° (on dried basis) |
| Related Substances (By HPLC) | N-deacetyl N-formyl thiocolchicoside: 0.5% max Colchicoside: 0.5% max Total unknown impurities: 0.5% max |
| Sulphated Ash | 0.1% max |
| Loss on Drying | 4.0% max |
| Residual Solvent (By GC) | Methanol: 3000 ppm max Ethanol: 5000 ppm max Acetone: 5000 ppm max Chloroform: 60 ppm max |
| Microbial Contamination | 1000 cfu/g max |
| Total Microbial Count | 100 cfu/g |
| Total Yeast and Mould Count | Absent /g |
| Escherichia coli | Absent /10 g |
| Salmonella | Absent /g |
| Staphylococcus aureus | Absent /g |
| Bacterial Endotoxin | 87.5 EU/mg max |
Applications
Thiocolchicoside is a semi-synthetic derivative of colchicoside widely used in pharmaceuticals for the management of muscle spasms, spasticity, and related neuromuscular disorders. It is commonly formulated for oral, injectable, and topical administration, providing muscle relaxation in conditions such as lumbar pain, cervical pain, and post-traumatic musculoskeletal stiffness. In addition to its clinical applications, Thiocolchicoside is used in pharmaceutical research as a reference compound for studying neuromuscular transmission, receptor binding, and muscle relaxant mechanisms. Its chemical structure allows exploration of structure–activity relationships in the development of next-generation muscle relaxants and anti-inflammatory agents.
Benefits
The benefits of Thiocolchicoside arise from its potent muscle relaxant activity, selective receptor interactions, and favorable pharmacokinetic properties. It acts as a GABAergic and glycine receptor modulator, providing effective relief of muscle tension and spasms with minimal central nervous system sedation compared to traditional muscle relaxants. Its semi-synthetic nature ensures higher stability and bioavailability compared to naturally occurring colchicoside, allowing predictable therapeutic effects. The compound is compatible with various pharmaceutical formulations, including tablets, capsules, and injectables, enabling flexibility in dosing and administration. Its well-characterized pharmacology and safety profile make it a reliable option for both acute and chronic musculoskeletal conditions.
Conclusion
Thiocolchicoside is a valuable semi-synthetic muscle relaxant used extensively in the management of spasticity, musculoskeletal pain, and neuromuscular disorders. Its selective receptor activity, chemical stability, and formulation versatility allow effective muscle relaxation with controlled dosing. By supporting therapeutic applications, pharmacological research, and the development of improved muscle relaxants, Thiocolchicoside remains an important compound in modern medicine and pharmaceutical research.
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