tert-Butyl trans-3-amino-4-(difluoromethyl)pyrrolidine-1-carboxylate

tert-Butyl trans-3-amino-4-(difluoromethyl)pyrrolidine-1-carboxylate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

This compound is primarily used in medicinal chemistry as a building block for the synthesis of pharmaceuticals, including enzyme inhibitors, receptor modulators, and CNS-active agents. The difluoromethyl group can improve bioavailability, metabolic stability, and molecular binding, while the trans-configured pyrrolidine ring introduces conformational rigidity that enhances target specificity. The Boc-protected nitrogen enables selective deprotection and further functionalization, facilitating incorporation into more complex molecules. In organic synthesis, it is used to prepare chiral intermediates, heterocyclic derivatives, and fluorinated compounds. The compound is also valuable in structure-activity relationship studies, helping chemists understand how fluorine substitution and stereochemistry affect biological activity and pharmacokinetic properties.

The benefits of tert-Butyl trans-3-amino-4-(difluoromethyl)pyrrolidine-1-carboxylate include its defined stereochemistry, chemical versatility, and fluorine-enhanced properties. The trans configuration ensures predictable stereochemical outcomes in multi-step syntheses, which is critical for producing enantiomerically pure drug candidates. The Boc-protected amine provides stability during reactions and can be selectively removed when needed. The difluoromethyl group enhances lipophilicity, metabolic resistance, and molecular recognition in biological systems. The compound is stable under standard laboratory conditions and soluble in common organic solvents, making it convenient for incorporation into diverse synthetic pathways.

In summary, tert-Butyl trans-3-amino-4-(difluoromethyl)pyrrolidine-1-carboxylate is a chiral, multifunctional pyrrolidine intermediate widely used in medicinal chemistry, organic synthesis, and fluorinated molecule design. Its stereochemical precision, Boc protection, and difluoromethyl functionality provide chemical versatility, metabolic stability, and structural rigidity. With its stability, reactivity, and ability to influence pharmacokinetic properties, it serves as a valuable building block for the synthesis of bioactive compounds, fluorinated analogues, and advanced chiral molecules.

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Tert-butyl (3R,4S)-3-amino-4-(difluoromethyl)pyrrolidine-1-carboxylate丨CAS 1428776-51-5

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