CAS · 6640-22-8
Product Overview
Sodium pamoate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Light yellow to yellow solid |
|---|---|
| Purity: | 98.00% min |
| Water (KF): | 3.7–4.5% |
| Sodium content: | 9.9–12.5% |
| Chlorine ion content: | 3.0% |
| Color of solution (UV): | 0.12% |
Applications
1. Pharmaceutical Salt Formation
Sodium pamoate is used to form pamoate salts with basic drugs (usually weak bases like alkaloids or amines).
This improves drug solubility, stability, and bioavailability by producing less soluble salts that can modify the release profile.
Common drugs formulated as pamoate salts include:
Propranolol pamoate (extended-release formulations)
Hydroxyzine pamoate
Chlorpheniramine pamoate
Helps in creating sustained-release oral formulations by slowing drug dissolution.
2. Extended-Release Injectable Formulations
Forms insoluble complexes with drugs enabling slow, controlled release from intramuscular or subcutaneous depots.
Used in formulations for long-acting injectable drugs such as antipsychotics and antiparasitic agents.
3. Suspending Agent in Oral Liquids
Enhances physical stability of suspensions by acting as a suspending agent, preventing settling of insoluble particles.
4. Veterinary Medicine
Employed in veterinary drugs to produce depot formulations with prolonged activity, reducing dosing frequency.
Benefits
✅ Improved Drug Stability and Bioavailability
By forming stable salts, sodium pamoate reduces drug degradation and enhances controlled absorption.
✅ Sustained and Controlled Drug Release
Enables extended dosing intervals, improving patient compliance.
✅ Versatile Compatibility
Can form salts with a variety of basic drugs, offering broad formulation options.
✅ Non-toxic and Biocompatible
Generally regarded as safe for pharmaceutical use with minimal adverse reactions.
✅ Cost-Effective Excipient
Relatively inexpensive and easy to incorporate in formulations.
Conclusion
Sodium pamoate (CAS 6640-22-8) is an essential pharmaceutical excipient primarily used to produce pamoate salts of basic drugs, facilitating controlled release and improved drug stability. Its role in both oral and injectable formulations supports enhanced therapeutic efficacy and patient adherence, making it widely utilized in both human and veterinary medicine.
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