CAS · 361-09-1
Product Overview
Sodium cholate丨361-09-1 is a salt of cholanic acid, a type of bile acid found naturally in the body. It is commonly used in pharmaceuticals, biochemistry, and biotechnology due to its detergent-like properties. It plays a role in lipid metabolism and is important in the study of membrane proteins and enzyme activities.
Product Specifications
| Property | Specification |
|---|---|
| Characteristics | White crystalline powder; Bitter taste, easy to absorb moisture |
| Assay | 98.0% min |
| Identify | The solution should be bluish-purple |
| Specific rotation | +35° to +42° (dry) |
| Light transmittance | 70.0% min |
| Melting Point | 225°C min |
| Loss on Drying | 5.0% max |
| Heavy metal | 20 ppm max |
| DCA | 1.0% max |
| PH | 6.5 to 9.5 (2% aqueous solution) |
| Unknown impurity | 0.5% max |
| Total impurity | 2.0% max |
Applications
1. Pharmaceutical Industry
● Used as a component in drug formulations to enhance the solubility and bioavailability of poorly soluble drugs.
● Acts as an emulsifier or stabilizing agent in certain pharmaceutical products.
● Investigated for its potential use in liver-related diseases, particularly in gallstone prevention and the regulation of cholesterol levels.
2. Biochemistry and Molecular Biology
● Commonly used in protein solubilization as it disrupts cell membranes and extracts membrane proteins, making it useful in studies involving cell membranes and membrane-bound enzymes.
● Employed in detergent-based assays for lipid extraction and analysis of lipoproteins.
● Utilized in lipidomic research and studies related to lipid bilayer properties and interactions.
3. Biotechnology and Drug Delivery
● Used as a carrier in drug delivery systems, particularly for liposome formation or as part of micelles that facilitate the encapsulation and delivery of hydrophobic drugs.
● Studies are being conducted to explore the use of sodium cholate in improving the delivery of vaccines and other bioactive compounds.
4. Veterinary Applications
● Sodium cholate is sometimes used in veterinary formulations to treat digestive issues or cholestasis, a condition characterized by bile flow obstruction.
5. Analytical and Diagnostic Applications
● Used in analytical chemistry for the extraction and analysis of lipids and other biological compounds.
● Serves as a detergent in protein purification processes, especially when solubilizing proteins from biological membranes.
Benefits
✅ Enhances Drug Solubility
● Increases the bioavailability of poorly soluble drugs, making it valuable in formulating drugs that otherwise wouldn't be well absorbed in the body.
✅ Facilitates Membrane Protein Study
● Its detergent properties help isolate membrane proteins for research, aiding in studies of membrane-bound enzymes and receptors.
✅ Supports Lipid and Lipoprotein Research
● Useful in lipid extraction and lipidomic studies, allowing for the examination of lipid bilayer structure and functions in biological systems.
✅ Biocompatible in Drug Delivery
● Can be used in drug delivery systems, particularly for delivering hydrophobic drugs, improving drug stability and targeted delivery.
✅ Helps in Cholesterol and Gallstone Regulation
● Investigated for its ability to regulate cholesterol metabolism and prevent gallstones, especially in conditions related to bile acid deficiencies.
Conclusion
Sodium cholate丨361-09-1 is a versatile and valuable compound used in a variety of fields, including pharmaceuticals, biochemistry, and biotechnology. Its role as a solubilizing agent, emulsifier, and membrane protein extractant makes it essential in drug development, lipid research, and protein studies. Moreover, its potential applications in improving drug solubility and aiding in lipid metabolism make it an important compound in both research and therapeutic settings.
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