Sodium Chenodeoxycholate

Sodium Chenodeoxycholate is a high-purity biochemical-reagents supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Pharmaceutical Applications

Gallstone Dissolution Therapy:

Used in the treatment of cholesterol gallstones (non-calcified).

Helps dissolve gallstones by reducing cholesterol saturation in bile.

Liver and Biliary Disorders:

Studied for treatment of primary biliary cholangitis and bile flow disorders.

May support cholagogue and hepato-protective formulations.

Drug Absorption Enhancer:

Improves the oral bioavailability of poorly soluble drugs by acting as a bile salt surfactant.

Useful in formulations of peptides or biologics to enhance intestinal absorption.

2. Biological Research

Commonly used in:

Membrane transport studies

Lipid metabolism research

Bile salt interaction with biological membranes and proteins

Used to solubilize membrane proteins or lipids in biochemical assays.

3. Nutraceutical and Functional Foods

May be included in liver support supplements or fat digestion aids.

Bile salt supplements like sodium chenodeoxycholate are considered in digestive enzyme formulations for patients with bile insufficiency.

4. Cell Culture and Biotech

Acts as a detergent or emulsifier in certain cell-based assays or protein purification steps.

Useful in biotransformation or enzyme reaction systems involving lipid substrates.

1. Natural Bile Salt with Physiological Relevance

As a primary bile salt, sodium chenodeoxycholate closely mimics the natural human bile acids.

Safe and effective for use in physiological and pharmaceutical contexts.

2. Promotes Lipid Digestion and Absorption

Aids micelle formation in the intestine, facilitating fat emulsification and absorption of fat-soluble vitamins (A, D, E, K).

3. Enhances Drug Solubility and Permeability

As a surfactant, it enhances the solubility of lipophilic drugs, and improves permeability across intestinal membranes.

4. Supports Non-Surgical Gallstone Treatment

Offers a non-invasive alternative for patients with cholesterol gallstones who are not suitable for surgery.

5. Biocompatible and Biodegradable

Metabolized naturally by the body, with minimal toxicological concerns when used appropriately.

Sodium chenodeoxycholate (CAS 2646-38-0) is a physiologically relevant bile salt used widely in pharmaceuticals, biomedical research, and functional health products. Its ability to dissolve cholesterol gallstones, enhance fat digestion, and improve drug absorption makes it a valuable compound in both therapeutic and formulation contexts. Its biocompatibility and surfactant-like behavior further extend its applications in cell culture, biochemistry, and nutraceuticals.

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