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Product Line: Pharmaceutical Chemicals

(S)-4-isobutyloxazolidine-2,5-dione

CAS 3190-70-3

Molecular structure of (S)-4-isobutyloxazolidine-2,5-dione

CAS · 3190-70-3

01

Product Overview

(S)-4-isobutyloxazolidine-2,5-dione is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

02

Product Specifications

Appearance White to off-white powder
Purity (HPLC) 95.0% min
¹H NMR Spectrum In accordance with structure
Melting Point 70.0 to 80.0 °C
Specific Rotation [α]D20 (C=1, CHCl₃) -37 to -43°
Isomer content 0.5% max
Water (K.F.) 1.0% max
03

Applications

(S)-4-isobutyloxazolidine-2,5-dione is a chiral building block widely used in pharmaceutical synthesis and organic chemistry. Its stereochemically defined oxazolidine-dione core makes it valuable for the preparation of optically active compounds, including amino acids, peptides, and heterocyclic intermediates. It is commonly employed in asymmetric synthesis, serving as a precursor or chiral auxiliary in the development of enantiomerically pure drugs. The compound is also used in the synthesis of beta-lactam derivatives, which are crucial scaffolds in antibiotic development and medicinal chemistry programs. Additionally, it finds applications in agrochemical research and fine chemical production, where stereoselective reactions are critical for bioactive molecule design. Its well-defined chiral center ensures high enantiomeric purity in downstream products, making it a preferred intermediate for researchers aiming to develop potent, selective, and safe therapeutic agents.

04

Benefits

The main benefits of (S)-4-isobutyloxazolidine-2,5-dione stem from its chiral integrity and chemical versatility. Its stereochemical purity enables precise control over reaction outcomes, allowing chemists to produce enantiomerically enriched compounds, which is essential for pharmaceuticals, as enantiomers often exhibit markedly different biological activity. The oxazolidine-dione moiety is stable under a variety of reaction conditions, yet reactive enough to participate in key transformations, including nucleophilic substitutions and ring-opening reactions, which facilitates the construction of diverse molecular architectures. Its predictable reactivity and compatibility with common reagents enhance synthetic efficiency, reduce byproducts, and improve overall yields. Furthermore, the compound's rigid structure aids in minimizing racemization, providing reliable results for asymmetric synthesis and ensuring consistent product quality in research and industrial applications.

05

Conclusion

(S)-4-isobutyloxazolidine-2,5-dione is a highly valuable chiral intermediate for pharmaceutical and chemical research. Its combination of stereochemical purity, structural stability, and versatile reactivity makes it ideal for the synthesis of enantiomerically pure drugs, peptides, and heterocyclic compounds. By facilitating precise asymmetric transformations and supporting the development of bioactive molecules with high selectivity, it plays a crucial role in medicinal chemistry, agrochemical design, and fine chemical production. Its reliability and effectiveness ensure that it remains an indispensable tool in the synthesis of advanced, optically active compounds.

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