CAS · 62965-57-5
Product Overview
(S)-2-AMino-3,3-diMethylbutanaMide is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off white powder |
|---|---|
| Purity | 98% min |
| IR | In accordance with the product |
| Specific rotation [α]D20 | N/A (C=1% in MeOH) |
| Water | 1.0% max |
| Loss on drying | 2.0% max |
| TLC | 98% min |
Applications
(S)-2-Amino-3,3-dimethylbutanamide is primarily used as a chiral building block and intermediate in pharmaceutical and chemical synthesis. It serves as a key component in the preparation of peptidomimetics, bioactive molecules, and amino acid derivatives with defined stereochemistry. In medicinal chemistry, it is applied in the design and synthesis of enzyme inhibitors, antiviral agents, and other therapeutic compounds where stereochemistry is crucial for biological activity. The compound is also employed in peptide chemistry to introduce steric bulk and enhance metabolic stability in peptide-based drugs. Additionally, it finds use in chemical research for asymmetric synthesis, stereoselective reactions, and the study of structure–activity relationships in chiral molecules.
Benefits
This compound offers several advantages due to its chiral and sterically hindered structure. The (S)-configuration ensures high enantiomeric purity, which is critical for the efficacy and selectivity of bioactive compounds. The 3,3-dimethyl substituents increase steric hindrance, enhancing metabolic stability and resistance to enzymatic degradation when incorporated into peptides or small molecules. Its amino and amide functionalities provide versatile reactive sites for coupling, derivatization, and further chemical modifications. The compound exhibits good solubility and chemical stability, enabling reliable performance in laboratory and industrial synthetic applications.
Conclusion
(S)-2-Amino-3,3-dimethylbutanamide is a valuable chiral intermediate with broad applications in pharmaceutical synthesis, peptide chemistry, and asymmetric organic synthesis. Its utility in constructing stereochemically defined, bioactive molecules, combined with benefits such as metabolic stability, high enantiomeric purity, and chemical versatility, makes it an essential building block in modern drug development and chemical research. The compound continues to support innovation in therapeutic design and stereoselective synthetic methodologies.
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