CAS · 1083076-69-0
Product Overview
RGH188 hydrochloride is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white to white powder |
|---|---|
| Identification RT (by HPLC) | Conform with reference standard |
| Purity | 99% min |
| P-XRD | Conform with reference standard |
| Dry weightlessness | 0.5% max |
| Heavy metal | 20 ppm max |
| Maximum single impurity | 0.15% max |
| Total impurity | 1% max |
| cis-isomer | 0.15% max |
| Residual solvents - Methanol | 3000 ppm max |
| Residual solvents - Ethyl Acetate | 5000 ppm max |
| Residual solvents - Acetonitrile | 410 ppm max |
| Assay (by HPLC) | 98%–102% |
Applications
RGH188 hydrochloride (CAS 1083076‑69‑0) is the hydrochloride salt of cariprazine, a novel atypical antipsychotic compound used extensively in neuroscience research and drug development. It is primarily applied as a research‑grade reference compound or active pharmaceutical intermediate to study dopaminergic and serotonergic signaling pathways, especially involving dopamine D₂ and D₃ receptors and 5‑HT₁A receptors. In preclinical pharmacological studies, it is used to characterize receptor binding profiles, signaling mechanisms, and dose–response relationships in vitro and in vivo, serving as a tool to evaluate antipsychotic efficacy, cognitive effects, and behavioral outcomes in animal models. Additionally, cariprazine hydrochloride is used in medicinal chemistry to support the synthesis and optimization of next‑generation psychotropic agents, providing a benchmark for comparing novel compounds targeting similar CNS pathways. Because of its well‑defined receptor interactions, it is also a standard compound in assays designed to screen for dopamine D₃/D₂ modulators and serotonergic modulators for psychiatric disorder research.
Benefits
The benefits of RGH188 hydrochloride stem from its distinct pharmacological profile and utility as a research tool in CNS drug discovery. As a highly selective partial agonist at dopamine D₃ and D₂ receptors, with particularly strong affinity for the D₃ subtype, it enables precise modulation of dopaminergic neurotransmission in experimental systems, helping researchers dissect complex neuropsychiatric mechanisms. Its moderate interaction with the 5‑HT₁A receptor further supports studies into mood, cognition, and anxiety‑related pathways. Because it mimics key aspects of atypical antipsychotic activity without requiring clinical dosing, cariprazine hydrochloride allows controlled investigation of behavioral and biochemical outcomes in models of schizophrenia, bipolar disorder, and other CNS disorders. Chemically, the hydrochloride salt is more stable and easier to handle than the free base, improving reproducibility in formulation and dosing during research applications. Its well‑characterized binding constants and documented receptor selectivity make it a reliable reference for comparative pharmacology and lead optimization in CNS therapeutic development.
Conclusion
RGH188 hydrochloride is a research‑focused form of cariprazine, valued for its high selectivity as a dopamine D₃/D₂ partial agonist and utility in neuroscience and psychiatric drug research. Its role as a reference compound and intermediate in preclinical studies supports the investigation of dopaminergic and serotonergic mechanisms related to antipsychotic activity, cognitive function, and mood regulation. The compound's stability as a hydrochloride salt and its well‑documented receptor profile make it an important tool in CNS drug discovery, enabling consistent, reproducible research that informs the design of advanced therapeutic agents.
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