CAS · 171228-49-2
Product Overview
Posaconazole is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White or off-white powder |
|---|---|
| Assay: | 98.0% ~ 102.0% |
| Solubility: | Soluble in dichloromethane; slightly soluble in methanol and acetone; slightly soluble in acetonitrile; extremely slightly soluble in isopropanol |
| Identification: | IR/HPLC; the spectrum time of each component peak in the test solution was the same as that in the system applicability solution (as tested in related substance) |
| Enantiomer: | 0.15% max |
| Specific Optical Rotation: | -24.5° ~ -28.5° |
| Crystal Form: | Should be crystalline I |
| Total Impurity: | 0.50% max |
| Other Single Impurity: | 0.15% max |
| PO-1: | 0.05% max |
| PO-2: | 0.05% max |
| PO-9: | 0.05% max |
| PO-10: | 0.05% max |
| Loss on Drying: | 0.5% max |
| Residue on Ignition: | 0.2% max |
| THF (Tetrahydrofuran): | 720 ppm max |
| EAC (Ethyl Acetate): | 5000 ppm max |
| Diethyl Ether: | 5000 ppm max |
Applications
1. Antifungal Treatment
Posaconazole丨CAS 171228-49-2 is a broad-spectrum antifungal agent used for the treatment and prevention of serious fungal infections caused by a wide range of pathogens, particularly in immunocompromised patients.
a. Prophylaxis (Prevention)
● Used to prevent invasive fungal infections in patients at high risk, such as:
Patients undergoing chemotherapy for acute myelogenous leukemia (AML) or myelodysplastic syndromes (MDS)
Recipients of hematopoietic stem cell transplants with graft-versus-host disease (GVHD)
Organ transplant patients receiving immunosuppressants
b. Treatment
● Treats infections caused by:
Aspergillus (aspergillosis)
Candida species (candidiasis, including oropharyngeal candidiasis)
Mucorales (mucormycosis, as salvage therapy)
Other rare molds and endemic fungi, such as Histoplasma and Coccidioides
2. Salvage Therapy
● Posaconazole丨CAS 171228-49-2 is frequently used as salvage therapy in patients who do not respond to or cannot tolerate other antifungals like amphotericin B or voriconazole.
● Particularly valuable for azole-resistant fungal strains, where few options remain.
3. Combination Therapy
● Occasionally employed in combination antifungal therapy with other drugs in refractory or disseminated fungal infections.
● Studied in protocols for severe cases of pulmonary aspergillosis and mucormycosis.
Benefits
1. Broad Antifungal Spectrum
● Effective against yeasts, molds, and dimorphic fungi.
● Inhibits the enzyme lanosterol 14α-demethylase, blocking ergosterol synthesis and disrupting fungal cell membrane integrity.
2. Favorable Safety Profile
● Generally well-tolerated, especially compared to amphotericin B, which can cause nephrotoxicity.
● Less hepatotoxic than some earlier azoles.
3. Versatile Formulations
● Available in oral suspension, delayed-release tablets, and IV form, making it suitable for various clinical scenarios:
Oral for prophylaxis and mild infections
IV for hospitalized or NPO (nothing by mouth) patients
4. Effective in Immunocompromised Populations
● Offers life-saving prophylaxis and treatment for:
Cancer patients
HIV/AIDS patients
Post-transplant patients
5. Long Half-Life
● Allows for once-daily dosing with delayed-release tablets, improving patient compliance and convenience.
Conclusion
Posaconazole丨CAS 171228-49-2 is a potent, broad-spectrum antifungal agent with crucial applications in preventing and treating invasive fungal infections, particularly in immunocompromised patients. Its efficacy, tolerability, and formulation versatility make it a frontline agent in modern antifungal therapy, especially in cases where other treatments fail or are not tolerated. As fungal resistance continues to rise, posaconazole plays an increasingly important role in advanced infectious disease management.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.